82586-66-1

Basic information

• Product Name: ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate
• Synonyms: ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate;4-Thiazolecarboxylicacid,2-[(dimethylamino)methyl]-,ethylester(9CI);2-[(Dimethylamino)methyl]-4-thiazolecarboxylic acid ethyl ester;Einecs 280-000-7
• CAS NO: 82586-66-1
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28466
• EINECS: 280-000-7
• Product Categories: THIAZOLE
• Mol File: 82586-66-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 282.5°Cat760mmHg
• Flash Point: 124.7°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.00334mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate(82586-66-1)
• EPA Substance Registry System: ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate(82586-66-1)

Safety Data

• Hazardous Substances Data: 82586-66-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate is a chemical compound with the molecular formula C11H16N2O2S. ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate is a thiazole derivative and contains an ethyl ester group, a thiazole ring, a carboxylic acid group, and a dimethylaminomethylene group. It is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its versatile chemical reactivity and biological activity. ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate has been studied for its potential as a drug candidate with various pharmacological properties, including antibacterial and antifungal activities. Additionally, it has been used as a building block in organic synthesis for the preparation of complex molecules.

InChI:InChI=1/C9H14N2O2S/c1-4-13-9(12)7-6-14-8(10-7)5-11(2)3/h6H,4-5H2,1-3H3

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 27507-28-4 ((dimethylamino)methyl)thioformamide 
• 506-59-2 N,N-dimethylammonium chloride 
• 78502-71-3 ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate 
• 842130-48-7 ethyl 2-(chloromethyl)thiazole-4-carboxylate 
• 27366-72-9 2-dimethylaminothioacetamide hydrochloride 

Downstream Products

• 82586-70-7 4-Hydroxymethyl-2-dimethylaminomethyl-thiazol-hydrochlorid 
• 199599-68-3 2-dimethylaminomethylthiazole-4-carboxaldehyde 
• 78441-69-7 2-dimethylaminomethyl-4-hydroxymethylthiazole 
• 78441-62-0 4-[[(2-aminoethyl)thio]-methyl]-N,N-dimethyl-2-thiazolemethanamine 

Relevant articles and documents

ANDROGEN RECEPTOR MODULATING COMPOUNDS

Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

C-2 basically substituted thiazoles with H2-antagonistic activity/21st Comm.: H2-antihistamines

In studies on structure-activity relationships of histamine H2-receptor antagonists, C-2 basically substituted thiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat. As a basic substituent the dimethylaminomethyl group is especially suitable, while cyclic guanidines lead to lower H2-antagonistic activity.

2-[2-(2-AMINOALKYL-4-THIAZOLYLMETHYLTHIO)ALKYL]-AMINO-5-SUBSTITUTED-4-PYRIMIDONES

2-2-(2-aminoalkyl-4-thiazolylmethylthio)-alkylene!amino-5-aromatic-substitute d alkylene-4-pyrimidones and related compounds, H. sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.