827344-01-4

Basic information

• Product Name: 2-Oxazolidinone,4-methyl-4-[(1E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]-,(4R)-(9CI)
• Synonyms: 2-Oxazolidinone,4-methyl-4-[(1E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]-,(4R)-(9CI)
• CAS NO: 827344-01-4
• Molecular Formula: C11H14N2O2
• Molecular Weight: 0
• Product Categories: METHYL
• Mol File: 827344-01-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Oxazolidinone,4-methyl-4-[(1E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]-,(4R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone,4-methyl-4-[(1E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]-,(4R)-(9CI)(827344-01-4)
• EPA Substance Registry System: 2-Oxazolidinone,4-methyl-4-[(1E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]-,(4R)-(9CI)(827344-01-4)

Safety Data

• Hazardous Substances Data: 827344-01-4(Hazardous Substances Data)

Upstream product

• 1618092-39-9 (4R)-4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one 
• 1192-58-1 N-methylpyrrole aldehyde 
• 1618092-42-4 {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 
• 1618092-41-3 (4S)-4-(iodomethyl)-4-methyl-1,3-oxazolidin-2-one 
• 1312772-35-2 methyl [(2S)-1-(benzyloxy)-3-hydroxy-2-methylpropan-2-yl]carbamate 

Relevant articles and documents

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1 agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.