- SWELL1-LRRC8 COMPLEX MODULATORS
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The present invention is directed to various polycyclic compounds and methods of using these compounds to treat a variety of diseases including metabolic diseases such as obesity, diabetes, nonalcoholic fatty liver disease; cardiovascular diseases such as hypertension and stroke; neurological diseases, male infertility, muscular disorders, and immune disorders.
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- Treatment of brain injury due to gray matter edema with (indanyloxy) butanoic acids
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The invention relates to the treatment and prevention of injury to the gray matter of the brain and to the spinal chord due to accidents, ischemic stroke, cardiac arrest, arrested breathing, Reye's syndrome and hydrocephalus by the administration of (indanyloxy)butanoic acids, their derivatives, analogs and salts thereof.
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- Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids
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Blunt and ischemic injuries of the brain have been shown to result in swelling that is predominantly limited to a single cell type, the astrocyte, within the complex cellular mosaic of cerebral gray matter. Evaluation of various diuretic (aryloxy)acetic a
- Cragoe Jr.,Gould,Woltersdorf Jr.,Ziegler,Bourke,Nelson,Kimelberg,Waldman,Popp,Sedransk
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p. 567 - 579
(2007/10/02)
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