- Method for preparing ceftobiprole analogues
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The invention relates to a method for preparing a ceftobiprole analogue as shown in a formula VII.
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Paragraph 0055-0058
(2020/08/09)
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- 5-Membered cyclic hydroxamic acids as HDAC inhibitors
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The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group. New reaction sequence was proposed for the synthesis of 5-membered alkylidene-cyc
- Mutule, Ilze,Borovika, Diana,Rozenberga, Elina,Romanchikova, Nadezhda,Zalubovskis, Raivis,Shestakova, Irina,Trapencieris, Peteris
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p. 216 - 223
(2015/04/14)
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- Indium-mediated reductive dehalogenation of α-halocarbonyl compounds in water
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Reactions of various α-halocarbonyl compounds 1 with indium in the presence of a catalytic amount of sodium dodecyl sulfate in water were performed to afford the corresponding parent carbonyl compounds 2 in excellent yields. The Royal Society of Chemistry 2000.
- Park, Leeyoung,Keum, Gyochang,Kang, Soon Bang,Kim, Kwan Soo,Kim, Youseung
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p. 4462 - 4463
(2007/10/03)
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- 7-(2-Aminomethyl-1-azetidinyl)-4-oxoquinoline-3-carboxylic acids as potent antibacterial agents: Design, synthesis, and antibacterial activity
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2-Aminomethyl-1-azetidinyl, -1-pyrrolidinyl, and -1-piperidinyl groups were designed as novel C-7 substituents for potential antibacterial quinolone agents. Of the three substituents, the 2-aminomethyl-1-azetidinyl group (compound 12a) was found to be the
- Fujita, Masahiro,Chiba, Katsumi,Tominaga, Yukio,Hino, Katsuhiko
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p. 787 - 796
(2007/10/03)
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- Synthesis of β-enaminoesters and lactams by Michael addition of N- benzylaniline to new allenic esters and lactams
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The synthesis of original allenic lactams 2 and allenic esters 5 is presented and their Michael condensation with N-benzylaniline described.
- Ibrahim-Ouali, Malika,Sinibaldi, Marie-Eve,Troin, Yves,Gardette, Daniel,Gramain, Jean-Claude
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p. 1827 - 1848
(2007/10/03)
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- 3-(3,5-di-tert-butyl-4-hydroxy benzylidene)-2-pyrrolidone and substituted derivatives thereof
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3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and N-substituted derivatives thereof are described. The substituent includes alkyl, alkoxy, alkynyl phenyl-alkylene, hydroxy-alkylene and amino-alkylene. They are effective as an anti-inflammatory
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- Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones
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A series of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones was synthesized and evaluated as candidate antiinflammatory/analgesic agents as well as dual inhibitors of prostaglandin and leukotriene synthesis. Some compounds that showed dual inh
- Ikuta,Shirota,Kobayashi,Yamagishi,Yamada,Yamatsu,Katayama
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p. 1995 - 1998
(2007/10/02)
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- Preparations of Perhydroimidazopyridine-3-thiones and Thiazole-5-spirocyclopropan-4(5H)-ones from Thioureas and α,γ-Dibromobutyryl Chloride under Phase-transfer Conditions
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The reaction of N-monosubstituted thioureas (1) with α,γ-dibromobutyryl chloride (2) was carried out in 5percent NaOH-CH2Cl2 to afford 2-alkyl(aryl)-6-bromo-2,3,7,8-tetrahydro-3-thioxo-6,8a-ethano-imidazopyridine-1,5(6H,8aH)-diones (3) and 2-alkyl(
- Okawara, Tadashi,Nakayama, Kentaro,Honda, Yoshihiro,Yamasaki, Tetsuo,Furukawa, Mitsuru
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p. 1733 - 1736
(2007/10/02)
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- Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions
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Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation
- Okawara, Tadashi,Matsuda, Takashi,Furukawa, Mitsuru
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p. 1225 - 1233
(2007/10/02)
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