832115-62-5 Usage
Uses
Used in Pharmaceutical Industry:
ISX 9 is used as a drug target for ischemic heart disease, as it exhibits regulatory effects towards the expression of pH sensing G protein-coupled receptor-68.
Used in Neurological Applications:
ISX 9 is used as a neuroregenerative agent to promote neurogenesis, enhance memory, and induce neuronal differentiation in adult neural stem cells.
Used in Diabetes Treatment:
ISX 9 is used to increase insulin production by pancreatic β cells, which can be beneficial for diabetes treatment.
Used in Cancer Therapy:
ISX 9 is used to block malignant astrocyte proliferation, downregulate their astrocyte character, induce reentry into the cell cycle, and upregulate neuronal gene expression, making it a potential therapeutic agent for glioma and other cancers involving astrocyte proliferation.
References
1) Petrik et al. (2012), Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule; FASEB J., 26 3148
2) Schneider et al. (2008), Small-molecule activation of neuronal cell fate; Nat. Chem. Biol., 4 408
3) Dioum et al. (2011), A small molecule differentiation inducers increases insulin production by pancreatic β cells; Proc. Natl. Acad. Sci. USA, 108 20713
4) Zhang et al. (2011), Small molecule blocks malignant astrocyte proliferation and induces neuronal gene expression; Differentiation, 81 233
4) Ali et al. (2016) Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule; Am. J. Stem. Cells 5 19
5) Bettio et al. (2016) ISX-9 can potentiate cell proliferation and neuronal commitment in the rat dentate gyrus; Neuroscience, 332 212
Check Digit Verification of cas no
The CAS Registry Mumber 832115-62-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,2,1,1 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 832115-62:
(8*8)+(7*3)+(6*2)+(5*1)+(4*1)+(3*5)+(2*6)+(1*2)=135
135 % 10 = 5
So 832115-62-5 is a valid CAS Registry Number.
832115-62-5Relevant articles and documents
Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines
Zhang, Xiao-Wei,He, Xiao-Lin,Yan, Nan,Zheng, Hong-Xing,Hu, Xiang-Guo
, p. 15726 - 15735 (2020/11/30)
A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.
Chemical inducers of neurogenesis
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Page/Page column 32, (2009/04/24)
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Comp
