Chemical Property of N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
Chemical Property:
- Boiling Point:468.1±35.0 °C(Predicted)
- PKA:13.60±0.20(Predicted)
- PSA：86.86000
- Density:1.39±0.1 g/cm3(Predicted)
- LogP:2.87010
- Storage Temp.:-20°
- Solubility.:Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml).
- XLogP3:1.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:234.04629874
- Heavy Atom Count:16
- Complexity:283
- Purity/Quality:
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99%, *data from raw suppliers
ISX 9 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3
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Description
ISX9 (832115-62-5) promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory.1?Induces robust neuronal differentiation in adult neural stem cells.2?Increases insulin production by pancreatic β cells.3?ISX9 blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression.4 Induces sensory neurons from neuroepithelial stem cells.5 Potentiates cell proliferation and neuronal commitment in the rat dentate gyrus.6
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Uses
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.
