- Design and Synthesis of Cyclic Mismatch-Binding Ligands (CMBLs) with Variable Linkers by Ring-Closing Metathesis and their Photophysical and DNA Repeat Binding Properties
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Cyclophane-containing bis(2-amino-1,8-naphthyridine) moieties attached to variable linkers at the C2-position (linker B) were synthesized as cyclic mismatch-binding ligands (CMBLs). Ring-closing metathesis (RCM) is used as a key step for the introduction
- Mukherjee, Sanjukta,Dohno, Chikara,Nakatani, Kazuhiko
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Read Online
- Synthesis method of imidazole additive
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The invention relates to a synthesis method of an imidazole additive, and belongs to the technical field of battery electrolyte additives. The method comprises the following steps of: taking allyl alcohol or propargyl alcohol as a raw material, introducing phosgene at a speed of 40-50mL/min at a temperature of 0DEG C or below, controlling the reaction temperature to be less than 5DEG C in the process of introducing phosgene for reaction, performing heat preservation treatment for 20-30min after the reaction is finished, introducing nitrogen into a reaction kettle for 1-1.5h at room temperature, performing reduced pressure distillation and collecting fractions for later use; adding dichloromethane and imidazole into a reaction kettle, adding triethylamine into the reaction kettle at a rate of 90-100mL/min, introducing nitrogen to replace gas in the reaction kettle after adding is completed, raising the temperature to a reflux temperature, adding the collected fraction dropwise into the reaction kettle, performing stirring for 3-5h after dropwise adding is completed, conducting suction filtration, washing separated mother liquor with alkali liquor till the pH value is 7.2-7.3, and conducting drying and reduced pressure distillation to obtain a product. The method is simple in synthetic route, easy to operate, low in energy consumption and few in by-product.
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Paragraph 0026-0034
(2021/05/12)
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- Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones
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A palladium-catalyzed decarboxylative asymmetric allylic alkylation (Pd-DAAA) of benzo-fused and non-benzo-fused δ-valerolactams is disclosed. This methodology gives access to chiral lactams bearing C3-quaternary stereocenters, which are central to many n
- Trost, Barry M.,Nagaraju, Anugula,Wang, Feijun,Zuo, Zhijun,Xu, Jiayi,Hull, Kami L.
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supporting information
(2019/03/19)
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- NANOPARTICLES FOR DRUG DELIVERY
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The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be induced to release the therapeutic agent from the core, through h
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Page/Page column 41; 42
(2016/04/20)
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- Studies on the enantioselective synthesis of carbazolones as intermediates in aspidosperma and kopsia alkaloid synthesis
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Two strategies for the assembly of homochiral carbazolones have been investigated. The first exploited desymmetrisation of 1,3-cyclohexadione derivatives however this failed to deliver satisfactory outcomes. An orthogonal route exploiting palladium catalysed decarboxylative allylation of racemic carbazolone β-ketoesters has been developed. Herein we report full details on the development of this reaction and clarify apparent discrepancies between our preliminary reports and those of Shao.
- Gartshore, Christopher J.,Lupton, David W.
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p. 882 - 890
(2013/09/12)
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- On the reactivity of imidazole carbamates and ureas and their use as esterification and amidation reagents
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The optimization, substrate scope, and mechanism of esterification and amidation of carboxylic acids mediated by imidazole-based reagents are discussed. The innate reactivity of carbonylimidazole reagents with a range of nucleophiles is also explored. New reagents developed for the synthesis of α,β-unsaturated esters are described, as are reagents for the preparation of tertiary amides directly from carboxylic acids.
- Heller, Stephen T.,Sarpong, Richmond
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body text
p. 8851 - 8859
(2011/12/02)
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- Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas
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Imidazole carbamates and ureas were found to be chemoselective esterification and amidation reagents. A wide variety of carboxylic acids were converted to their ester or amide analogues by a simple synthetic procedure in high yields.
- Heller, Stephen T.,Sarpong, Richmond
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supporting information; experimental part
p. 4572 - 4575
(2010/12/25)
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- Synthesis of allyl selenides by palladium-catalyzed decarboxylative coupling
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This communication details the Pd-catalyzed decarboxylation of selenocarbonates; use of a chiral nonracemic catalyst affords enantioenriched allyl selenides which undergo stereospecific [2,3]-sigmatropic rearrangements to form enantioenriched allylic amines and chlorides. The Royal Society of Chemistry.
- Waetzig, Shelli R.,Tunge, Jon A.
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supporting information; experimental part
p. 3311 - 3313
(2009/02/04)
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- The O-acylation of ketone enolates by allyl 1H-imidazole-1-carboxylate mediated with boron trifluoride etherate - A convenient procedure for the synthesis of substituted allyl enol carbonates
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(Chemical Equation Presented) A convenient access to substituted allyl enol carbonates was established through the reaction of ketone enolates with the complex of allyl 1H-imidazole-1-carboxylates and boron trifluoride etherate.
- Trost, Barry M.,Xu, Jiayi
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p. 9372 - 9375
(2008/03/13)
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- Surface modification with orthogonal photosensitive silanes for sequential chemical lithography and site-selective particle deposition
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(Chemical Equation Presented) Monolayer lithography: The concept of orthogonal cleavage of photolabile protecting groups was demonstrated with self-assembled silane layers on solid surfaces. Nitroveratryloxycarbonyl and benzoin derivatives can be addresse
- Del Campo, Aranzazu,Boos, Diana,Spiess, Hans Wolfgang,Jonas, Ulrich
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p. 4707 - 4712
(2007/10/03)
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- SYNTHESIS OF ENOL CARBONATES FROM A REACTION OF SILYL ENOLATES WITH 1H-IMIDAZOLYLURETHANE
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Enol carbonates (6) were prepared by treatment of trimethylsilyl enolates (5) with 1-alkoxycarbonyl-1H-imidazoles (2) in the presence of boron trifluoride etherate and tetrabutylammonium fluoride.
- Ohta, Shunsaku,Yamashita, Masayuki,Nagai, Nobuaki,Kawasaki, Ikuo,Maeda, Kazuto,Miyano, Yoshiko
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p. 1683 - 1690
(2007/10/03)
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