83674-71-9

Basic information

• Product Name: 2,4-DIIODOPYRIDINE
• Synonyms: 2,4-DIIODOPYRIDINE
• CAS NO: 83674-71-9
• Molecular Formula: C5H3I2N
• Molecular Weight: 330.89
• Product Categories: Pyridines
• Mol File: 83674-71-9.mol

Chemical Properties

• Boiling Point: 316.8 °C at 760 mmHg
• Flash Point: 145.4 °C
• Appearance: /
• Density: 2.609 g/cm³
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.721
• CAS DataBase Reference: 2,4-DIIODOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIIODOPYRIDINE(83674-71-9)
• EPA Substance Registry System: 2,4-DIIODOPYRIDINE(83674-71-9)

Safety Data

• Hazardous Substances Data: 83674-71-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diiodopyridine is used as a synthetic intermediate for the production of nicotelline-d8 (N401202). Nicotelline is a biomarker and environmental tracer for tobacco smoke, and its isotope-labelled form serves as a nicotine-related metabolite with potential as an inhibitor of human cytochrome P-450 2A6. This makes 2,4-Diiodopyridine an essential component in the development of drugs and therapies targeting nicotine addiction and tobacco-related health issues.

InChI:InChI=1/C5H3I2N/c6-4-1-2-8-5(7)3-4/h1-3H

Upstream product

• 88511-26-6 2-iodo-pyridin-4-ylamine 
• 26452-80-2 2,4-dichloropyridine 
• 5029-67-4 2-iodopyridine 
• 52092-44-1 2-iodo-4-nitropyridine N-oxide 

Downstream Products

• 1062609-45-3 (4-iodo-pyridin-2-yl)-dimethyl-amine 
• 396092-83-4 (2-iodo-pyridin-4-yl)-dimethyl-amine 
• 26274-35-1 2,4-diphenylpyridine 

Relevant articles and documents

SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS

This invention relates to compounds of formula (I), their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

Iodopyridines from bromo- and chloropyridines

Bromo- and chloropyridines may be converted to the corresponding iodopyridines by treatment with sodium iodide and acetyl chloride in acetonitrile.

Studies on Organometallic Compounds. II. Facile and Convenient Method for the Synthesis of Idoazines through Iododestannation of Trimethylstannylazines

Trimethylsatannyl and bis(trimethylstannyl) derivatives of pyridine, quinoline, and isoquinoline were prepared from the corresponding halo and dihalo (chloro or bromo) derivatives and trimethylstannyl sodium, which was generated in situ from chlorotrimethylsatannane and sodium.These stannyl derivatives readily underwent iododestannation on treatment with iodine to produce the corresponding iodo and diiodo derivatives of pyridine, quinoline, and isoquinoline, respectively, in good yields.Keywords -trimethylsannylazine; bis(trimethylstannyl)azine; iodoazine; diiodoazine; iododestannation; trimethylstannyl sodium; chlorotrimethylstannane