- METHOD FOR PRODUCING GLYCYRRHIZINIC ACID AND GALACTURO GLYCYRRHIZINIC ACID, AND INTERMEDIATE USED FOR THE PRODUCTION METHOD
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PROBLEM TO BE SOLVED: To provide a synthesis method that makes it possible to produce high-purity glycyrrhizinic acid or galacturo glycyrrhizinic acid, simply and in high yields. SOLUTION: A production method includes performing glycosylation of position-3 hydroxy group of glycyrrhetinic acid, then performing selective galactosylation or glycosylation at position-2', and through deprotection, performing selective oxidation of a primary hydroxy group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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Paragraph 0039; 0045
(2018/07/28)
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- TRANSFORMATIONS OF GLYCYRRHIZIC ACID. III.* SYNTHESIS OF NEW GLYCOPEPTIDES CONTAINING METHYL ESTERS OF AMINO ACIDS
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A new selective method has been proposed for the preparation of glycopeptides of β-glycyrrhizic acid (I) containing fragments of methyl esters of amino acids by reacting tris-N-hydroxysuccinimidic ester of a glycoside, obtained in situ using N,N'-dicyclohexylcarbodiimide, with hydrochlorides of methyl esters of amino acids or dipeptides in the presence of triethylamine.
- Baltina, L. A.,Tolstikov, G. A.
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p. 1115 - 1120
(2007/10/02)
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