- Microwave assisted sulfopropylation of N-heterocycles using 1,3-propane sultone
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Dramatic rate acceleration was observed for N-sulfopropylation of heterocyclic compounds (1a-h) using 1,3-propane sultone(2) under microwave irradiation affording the N-sulfopropylated compounds (3a-h) in 68-95% yield.
- Adamczyk, Maciej,Rege, Sushil
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p. 9587 - 9588
(2007/10/03)
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- Syntheses of Fluorescent Dyes. XIV. Standards for Fluorescent Measurements in the Near Neutral pH-Range
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Highly fluorescent cationic indicators have been obtained by reaction of heterocyclic nitrogen bases with 1,3-propane sultone.Unlike the bases themselves, the fluorescence intensity of the cationic salts is practically pH-independent in the neutral pH-range, which makes them useful reference substances in measuring fluorescence intensities in physiological studies.Furthermore, they are sufficiently water soluble, the fluorescence maxima covering the wavelength range from 440 to 530 nm. 2-(3-Sulfonatopropyl)harmanium, (5) appears to be the most useful compound for intra- and extracellular liquids, since its fluorescence is not quenched by chloride ion.
- Wolfbeis, Otto S.,Urbano, Edmund
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p. 841 - 843
(2007/10/02)
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