Efficient S-alkylation of cysteine in the presence of 1,1,3,3- tetramethylguanidine
The synthesis of S-alkylated cysteine derivatives was carried out successfully in the presence of 1,1,3,3-tetramethylguanidine. Alkylation proceeded in high yields on unprotected amino acids and peptides containing a sulfhydryl group.
W?ostowski, Marek,Czarnocka, Sylwia,MacIejewski, Piotr
experimental part
p. 5977 - 5979
(2010/11/21)
Novel N,S-phenacyl protecting group and its application for peptide synthesis
The phenacyl group can be introduced onto amino and thio groups by N,S-alkylation reactions. Conversely, these groups are removed rapidly by employing magnesium in acetic acid. This protecting group was successfully applied to a short peptide synthesis of Boc-L-Cys-Gly-OMe. Georg Thieme Verlag Stuttgart.
Tang, Guo,Ji, Tao,Hu, An-Fu,Zhao, Yu-Fen
scheme or table
p. 1907 - 1909
(2009/04/11)
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