Organocatalytic direct difluoromethylation of aldehydes and ketones with TMSCF2H
An organic Lewis base promoted direct difluoromethylation reaction of carbonyl compounds with Me3SiCF2H has been studied. The Schwesinger's superbase can efficiently activate the Si-CF2H bond and initiate the difluoromethy
Du, Guang-Fen,Wang, Ying,Gu, Cheng-Zhi,Dai, Bin,He, Lin
p. 35421 - 35424
(2015/05/05)
Efficient and direct nucleophilic difluoromethylation of carbonyl compounds and imines with Me3SiCF2H at ambient or low temperature
Since 1995, Me3SiCF2H has been widely believed to be an inefficient difluoromethylating agent, which requires harsh reaction conditions to cleave its rather inert Si-CF2H bond. However, it has now been found that, by using