Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis
Asymmetric reductive amination of poorly nucleophilic sulfonamides was realized in the presence of nickel catalysts and titanium alkoxide. A wide range of ketones, including enolizable ketones and some biaryl ones, were converted into sulfonamides in excellent enantiomeric excess. The cyclization of sulfamates and intermolecular reductive amination of a diarylphosphinamide were also successful. Formic acid was used as a safe and economic surrogate of high-pressure hydrogen gas.
Zhao, Xiaohu,Xu, Haiyan,Huang, Xiaolei,Zhou, Jianrong Steve
supporting information
p. 292 - 296
(2018/12/13)
Direct Synthesis of Enolizable N-Sulfonyl Ketimines under Microwave Irradiation
N-sulfonyl imines are widely used as substrates for a range of transformations. Access to N-sulfonyl aldimines is straightforward through direct condensation between the parent aldehyde and the sulfonamide. However, this approach is not efficient for the
Ortiz, Pablo,Collados, Juan F.,Harutyunyan, Syuzanna R.
supporting information
p. 1247 - 1250
(2016/03/19)
Reduction of sulfonylimines with raney nickel
Raney-Ni/EtOH reduction of different N-sulfonylimines provides a new entry for synthesizing sulfonamides in good yields under mild conditions. This protocol, which does not require additional hydrogen, constitutes a cheap, safe, and easy-to-handle alterna
Ruano, Jose Luis Garca,Fernandez-Salas, Jose A.,Maestro, M. Carmen,Parra, Alejandro
p. 198 - 207,10
(2020/09/02)
Preparation of N-p-tolylsulfonyl-(E)-1-phenylethylideneimine
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Ruano, José Luis García,Alemán, José,Parra, Alejandro,Belén Cid,Oisaki, Kounosuke,Shibasaki, Masakatsu
p. 129 - 138
(2017/09/25)
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