- Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex
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(Chemical Equation Presented) o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethyl-styrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp 2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.
- Ikeuchi, Yutaka,Taguchi, Takeo,Hanzawa, Yuji
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p. 756 - 759
(2007/10/03)
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