cas 84487-15-0, 2-Bromo-5-nitropyridin-4-amine

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Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
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Paragraph 0254

(2020/02/19)

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
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Paragraph 0303; 0304

(2019/02/13)

Structure-based drug design of novel, potent, and selective azabenzimidazoles (ABI) as ATR inhibitors
Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion channel inhibition. DMPK experiments established that CYP P450 and AO metabolism in conjunction with Pgp and BCRP efflux were major causative mechanisms for the observed PK. The series also harbored the CYP3A4 TDI liability driven by the presence of both a morpholine and an indole moiety. Incorporation of an adjacent fluorine or nitrogen into the 6-azaindole addressed many of the various medicinal chemistry issues encountered. (Chemical Presented).
Barsanti, Paul A.,Pan, Yue,Lu, Yipin,Jain, Rama,Cox, Matthew,Aversa, Robert J.,Dillon, Michael P.,Elling, Robert,Hu, Cheng,Jin, Xianming,Knapp, Mark,Lan, Jiong,Ramurthy, Savithri,Rudewicz, Patrick,Setti, Lina,Subramanian, Sharadha,Mathur, Michelle,Taricani, Lorena,Thomas, George,Xiao, Linda,Yue, Qin
p. 42 - 46
(2015/01/30)

PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS
Novel inhibitors of Rho-kinases are disclosed.
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(2008/06/13)

Chemical Properties

Boiling Point: 396.3 °C at 760 mmHg
Flash Point:193.5 °C
Density: 1.929 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 1.72E-06mmHg at 25°C
Refractive Index: 1.682
PKA: 0.79±0.42(Predicted)
PSA: 84.73000
LogP: 2.43890

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Chemical Properties

Boiling Point: 396.3 °C at 760 mmHg

Flash Point:193.5 °C

Density: 1.929 g/cm³

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 1.72E-06mmHg at 25°C

Refractive Index: 1.682

PKA: 0.79±0.42(Predicted)

PSA: 84.73000

LogP: 2.43890

Global suppliers and manufacturers of 84487-15-0total 39 suppliers on LookChem

Article Database

84487-15-0

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Chemical Properties

Boiling Point: 396.3 °C at 760 mmHg

Flash Point:193.5 °C

Density: 1.929 g/cm3

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 1.72E-06mmHg at 25°C

Refractive Index: 1.682

PKA: 0.79±0.42(Predicted)

PSA: 84.73000

LogP: 2.43890

Global suppliers and manufacturers of 84487-15-0total 39 suppliers on LookChem

Density: 1.929 g/cm³