84487-15-0

Basic information

• Product Name: 2-BROMO-5-NITROPYRIDIN-4-AMINE
• Synonyms: 2-BROMO-5-NITROPYRIDIN-4-AMINE;4-Amino-2-bromo-5-nitropyridine;2-BroMo-5-nitro-4-pyridinaMine;4-AMino-2-broMo-5-nitropy...;(2-Bromo-5-nitropyridin-4-yl)amine;2-broMo-5-nitropyridin-4-aMino
• CAS NO: 84487-15-0
• Molecular Formula: C₅H₄BrN₃O₂
• Molecular Weight: 218.02
• Mol File: 84487-15-0.mol

Chemical Properties

• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.5 °C
• Appearance: /
• Density: 1.929±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.79±0.42(Predicted)
• CAS DataBase Reference: 2-BROMO-5-NITROPYRIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-NITROPYRIDIN-4-AMINE(84487-15-0)
• EPA Substance Registry System: 2-BROMO-5-NITROPYRIDIN-4-AMINE(84487-15-0)

Safety Data

• Hazardous Substances Data: 84487-15-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-5-nitropyridin-4-amine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 2-Bromo-5-nitropyridin-4-amine is used as a precursor in the production of agrochemicals, helping to create compounds that can protect crops from pests and diseases.
Used in Dye Manufacturing:
2-Bromo-5-nitropyridin-4-amine is utilized as a building block in the manufacturing of dyes, contributing to the creation of a range of colorants for various applications.
Used in Organic Synthesis:
As a key component in organic synthesis, 2-Bromo-5-nitropyridin-4-amine is used for the preparation of heterocyclic compounds, which are vital in medicinal and agricultural chemistry for their diverse applications.
Used in Biological Research:
2-Bromo-5-nitropyridin-4-amine is employed in biological research as a compound with potential anti-cancer and anti-inflammatory properties, making it a candidate for further study and development in therapeutic applications.

InChI:InChI=1/C5H4BrN3O2/c6-5-1-3(7)4(2-8-5)9(10)11/h1-2H,(H2,7,8)

Upstream product

• 4487-57-4 2,4-dibromo-5-nitropyridine 
• 31872-62-5 4-methoxy-3-nitro-pyridine 
• 607373-82-0 2-hydroxy-4-methoxy-5-nitro pyridine 

Downstream Products

• 850663-98-8 methyl 3-[(4-amino-5-nitro-2-pyridinyl)oxy]benzoate 
• 1332875-74-7 5-nitro-2-(2-trifluoromethyl-phenyl)-pyridin-4-ylamine 
• 1332875-75-8 2-chloro-6-(2-trifluoromethyl-phenyl)-pyridine-3,4-diamine 
• 1332875-76-9 3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile 
• 1332875-94-1 2-(3-tert-butyl-isoxazol-5-yl)-4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine 
• 1033203-41-6 6-bromopyridine-3,4-diamine 
• 850664-00-5 methyl 3-[(4,5-diamino-2-pyridinyl)oxy]benzoate 
• 850663-97-7 methyl 3-{[2-(4-amino-furazan-3-yl)-1H-imidazo[4,5-c]pyridin-6-yl]oxy}benzoate 

Relevant articles and documents

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

Structure-based drug design of novel, potent, and selective azabenzimidazoles (ABI) as ATR inhibitors

Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion channel inhibition. DMPK experiments established that CYP P450 and AO metabolism in conjunction with Pgp and BCRP efflux were major causative mechanisms for the observed PK. The series also harbored the CYP3A4 TDI liability driven by the presence of both a morpholine and an indole moiety. Incorporation of an adjacent fluorine or nitrogen into the 6-azaindole addressed many of the various medicinal chemistry issues encountered. (Chemical Presented).

PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS

Novel inhibitors of Rho-kinases are disclosed.