845616-49-1

Basic information

• Product Name: 1,2,4-Trifluoro-5-(methylsulfonyl)benzene
• Synonyms: 1,2,4-Trifluoro-5-(methylsulfonyl)benzene
• CAS NO: 845616-49-1
• Molecular Formula: C₇H₅F₃O₂S
• Molecular Weight: 210.174
• Mol File: 845616-49-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,4-Trifluoro-5-(methylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Trifluoro-5-(methylsulfonyl)benzene(845616-49-1)
• EPA Substance Registry System: 1,2,4-Trifluoro-5-(methylsulfonyl)benzene(845616-49-1)

Safety Data

• Hazardous Substances Data: 845616-49-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Trifluoro-5-(methylsulfonyl)benzene is utilized as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure and properties make it a valuable component in the creation of molecules with specific biological activities and medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1,2,4-Trifluoro-5-(methylsulfonyl)benzene serves as a key intermediate in the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in agricultural applications, such as pest control and crop protection, while maintaining environmental sustainability.
Used in Material Science:
1,2,4-Trifluoro-5-(methylsulfonyl)benzene is employed as a building block in the development of materials with specific electronic and optical properties. Its unique characteristics allow for the engineering of materials that can be used in various high-tech applications, such as in the fields of electronics, photonics, and optoelectronics.
Used in Organic Chemistry Research and Development:
Due to its versatility and the potential for novel reactions and syntheses, 1,2,4-Trifluoro-5-(methylsulfonyl)benzene is a subject of significant research and development efforts within the field of organic chemistry. It provides a platform for exploring new chemical reactions, mechanisms, and the synthesis of complex organic molecules with potential applications in various industries.

Upstream product

• 558-25-8 methyl fluorosulfonate 
• 367-23-7 1,2,4-trifluorobenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 74-88-4 methyl iodide 
• 79-08-3 bromoacetic acid 
• 845616-48-0 2,4,5-trifluorobenzenesulfinic acid 
• 220227-21-4 2,4,5-trifluorobenzene-1-sulfonyl chloride 

Downstream Products

• 1351166-50-1 (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate 
• 1351168-24-5 (S)-tert-butyl 3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4'-bipiperidine-1'-carboxylate 
• 1351168-87-0 (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride 
• 1351166-57-8 (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-ethylpyrimidin-2-yl)-[1,4'-bipiperidin]-2-one 
• 1351166-65-8 (S)-1'-(5-chloropyrazin-2-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one 
• 1351166-72-7 (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-o-tolylpyrazin-2-yl)-[1,4'-bipiperidin]-2-one 
• 1351168-30-3 (S)-1'-(5-acetylpyridin-2-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one 
• 1351166-75-0 (3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one 
• 1351167-92-4 (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one 
• 1351166-11-4 (S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one 
• 1351166-89-6 (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1'-(5-ethylpyrimidin-2-yl)-[1,4'-bipiperidin]-2-one 
• 1351168-05-2 (S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate 
• 1433881-57-2 (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one 

Relevant articles and documents

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, X3, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X1, X2, L, R3, R4, R5, R6, R6a, R7, R9, R9a, and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

Compounds of Formula (I) wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

BENZOYL-PIPERAZINE DERIVATIVES

The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

Methanesulfonylation of deactivated aromatics with superelectrophilic CH3so2F·3SbF5 and (CH3so2)2O-2CF3so 3H/B(O3SCF3)3 systems

Methanesulfonylation of various deactivated arenes, including tri- and tetrafluorobenzenes, was achieved in good yield under mild conditions using superelectrophilic CH3SO2F/3SbF5 and (CH3SO2O)2O/2CF3SO 3H-B(O3SCF3)3 reagent systems. 1998 MAHK "Hayka/Interperiodica".