845827-13-6

Basic information

• Product Name: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-
• Synonyms: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-;5-Bromo-alpha,alpha-difluoro-2-picoline;3-Bromo-6-(difluoromethyl)pyridine;5-Bromo-2-(difluoromethyl)pyridine 95%
• CAS NO: 845827-13-6
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• EINECS: 200-258-5
• Mol File: 845827-13-6.mol

Chemical Properties

• Melting Point: 35-40℃
• Boiling Point: 206.644 °C at 760 mmHg
• Flash Point: 89°(192°F)
• Appearance: White to yellow/Solid
• Density: 1.64
• Storage Temp.: 2-8°C
• PKA: -0.83±0.29(Predicted)
• CAS DataBase Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)
• EPA Substance Registry System: PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)-(845827-13-6)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 845827-13-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for a wide range of reactions, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)is employed as a starting material or a synthetic intermediate for the development of new drugs. Its presence in the molecular structure can impart specific properties to the final product, such as improved pharmacokinetics, enhanced potency, or targeted delivery.
Used in Agrochemicals:
PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)may also find applications in the agrochemical sector, where it can be used as a component in the synthesis of pesticides, herbicides, or other crop protection agents. Its unique chemical properties can contribute to the development of more effective and environmentally friendly products.
Used in Materials Science:
In the field of materials science, PYRIDINE, 5-BROMO-2-(DIFLUOROMETHYL)has potential applications in the development of new materials with specific properties. Its incorporation into polymers, coatings, or other materials can lead to improved performance, such as enhanced stability, increased resistance to environmental factors, or tailored chemical reactivity.

Upstream product

• 223463-13-6 2-iodo-5-bromopyridine 
• 1438388-96-5 tributyl(difluoromethyl)stannane 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 294181-95-6 2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester 

Downstream Products

• 845826-93-9 4-[6-(difluoromethyl)-pyridin-3-yl]benzenecarboxylic acid 

Relevant articles and documents

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

NEW ANTI-MALARIAL AGENTS

The present invention is related to new derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to dihydroisoquinoline derivatives useful for the preparation of a pharmaceutical for

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

Deoxyfluorination of (Hetero)aryl Aldehydes Using Tetramethylammonium Fluoride and Perfluorobutanesulfonyl Fluoride or Trifluoromethanesulfonic Anhydride

This Communication describes the conversion of (hetero)aryl aldehydes into the corresponding (hetero)aryl difluoromethyl products using anhydrous NMe4F in combination with perfluorobutanesulfonyl fluoride or trifluoromethanesulfonic anhydride.

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.

3-OXO-6-HETEROARYL-2-PHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES

The present invention covers 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine- 4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER

The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I), in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Manufacturing method of making heteroarylacetic compd. defluoromethyl

PROBLEM TO BE SOLVED: To provide a method for easily producing a difluoromethyl heteroaryl compound with high yield at low cost. SOLUTION: In the method for producing the difluoro methyl heteroaryl compound, a halogenated heteroaryl compound and a α-silyldifluoro acetate ester compound are reacted with each other in the presence of a metal halogenated compound. COPYRIGHT: (C)2012,JPOandINPIT

HETEROARYL SYK INHIBITORS

The invention relates to new substituted heteroarylsof formula (1) wherein A is selected from the group consisting of N and CH, D is selected from the group consisting of S and O, E is C, T is C, G is C, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.

NOVEL 4-AMINO-6-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PICOLINATES AND 6-AMINO-2-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinic acids and their derivatives; 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.