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294181-95-6

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294181-95-6 Usage

General Description

Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a chemical compound with the formula C9H8BrF2NO2. Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a difluoroacetate ester and contains a 5-bromopyridine moiety. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of complex organic molecules. Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a colorless liquid with a molecular weight of 263.07 g/mol. It is important to handle this chemical with caution, as it may have harmful effects if ingested, inhaled, or in contact with the skin or eyes.

Check Digit Verification of cas no

The CAS Registry Mumber 294181-95-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,4,1,8 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 294181-95:
(8*2)+(7*9)+(6*4)+(5*1)+(4*8)+(3*1)+(2*9)+(1*5)=166
166 % 10 = 6
So 294181-95-6 is a valid CAS Registry Number.

294181-95-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate

1.2 Other means of identification

Product number -
Other names 2-pyridineacetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:294181-95-6 SDS

294181-95-6Relevant articles and documents

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

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Paragraph 0036-0042; 0051, (2020/12/30)

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

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Page/Page column 74; 73, (2018/07/05)

The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2', R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

METALLOENZYME INHIBITOR COMPOUNDS

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Page/Page column 79; 80, (2017/07/31)

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

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