845866-81-1

Basic information

• Product Name: 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE
• Synonyms: 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE;BENZENE, 2-BROMO-1-(DIFLUOROMETHYL)-4-FLUORO-;2-bromo-4-fluorobenzodifluoride
• CAS NO: 845866-81-1
• Molecular Formula: C₇H₄BrF₃
• Molecular Weight: 225.01
• Mol File: 845866-81-1.mol

Chemical Properties

• Boiling Point: 194.4°C at 760 mmHg
• Flash Point: 77℃
• Appearance: /
• Density: 1.711 g/mL at 25 °C
• Vapor Pressure: 0.62mmHg at 25°C
• Refractive Index: n20/D1.495
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE(845866-81-1)
• EPA Substance Registry System: 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE(845866-81-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 23-26-36
• WGK Germany: 3
• Hazardous Substances Data: 845866-81-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of complex organic molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE is utilized as an intermediate in the production of agrochemicals, playing a role in the creation of compounds that can enhance crop protection and yield.
Used in Chemical Synthesis:
2-BROMO-1-DIFLUOROMETHYL-4-FLUOROBENZENE is employed as a building block in the synthesis of various organic compounds, leveraging its reactivity to form new molecules with diverse applications across different industries.

InChI:InChI=1/C7H4BrF3/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3,7H

Upstream product

• 59142-68-6 2-bromo-4-fluorobenzaldehyde 

Downstream Products

• 1166820-28-5 2-difluoromethyl-5-fluorobenzaldehyde 
• 1402602-07-6 methyl 3-(4-((2-(difluoromethyl)-5-fluorophenyl)ethynyl)-2-fluorophenyl)propanoate 

Relevant articles and documents

FUSED IMIDAZOLE DERIVATIVES AS AHR ANTAGONISTS

The present disclosure relates to compounds of formulae (I) - (VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.

SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF THE ARYL HYDROCARBON RECEPTOR (AHR)

The present invention relates to bicyclic compounds which can act as aryl hydrocarbon receptor (AhR) modulators and, in particular, as AhR antagonists. The invention further relates to the use of the compounds for the treatment and/or prophylaxis of diseases and/or conditions through binding of said aryl hydrocarbon receptor by said compounds. A-B-L-C (I)

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.