- Plantes de Nouvelle-Caledonie. 124. Taxanes isoles des ecorces de tronc d'Austrotaxus spicata Compton (Taxacees)
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Eighteen taxane-type diterpenes have been isolated from the trunk bark of Austrotaxus spicata: thirteen are alkaloids.Eight compounds have an exocyclic-4(20) methylene group: austrospicatine, 2'-desacetyl-austrospicatine, 2'-desacetoxyaustrospicatine, already found in the leaves of the same plant, comptonine, spicaledonine, 7β,9α,10β-triacetoxy 2α,5α,13α-trihydroxy 4(20),11-taxadiene, 2',13α,14β-tridesacetylaustrotaxine and 7β,9α-diacetoxy 5α,13α,14β-trihydroxy 10-oxo 4(20),11-taxadiene which are described here for the first time.The ten other compounds have an epoxide group in position 4(20): spicataxine, 9α-acetyl 10β-desacetylspicataxine, spicatine, 9α-acetyl 10β-desacetylspicatine, 10β-desacetylspicatine, nicaustrine, N-demethylnicaustrine, nicotaxine, 5α-O-(3'-methylamino 3'-phenylpropionyl)nicotaxine and 5α-O-(3'-amino 3'-phenylpropionyl)nicotaxine: all these products are new, the last five are original by owning a nicotinic substituent.The structures have been established from the spectral data, mainly from MS, 1H and 13C NMR spectra.
- Ettouati, Laurent,Ahond, Alain,Convert, Odile,Poupat, Christiane,Potier, Pierre
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p. 687 - 694
(2007/10/02)
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