847604-18-6

Basic information

• Product Name: 2-chloro-4-methoxyphenylacetic acid methyl ester
• Synonyms: Methyl 2-(2-chloro-4-methoxyphenyl)acetate;2-chloro-4-methoxyphenylacetic acid methylester;2-chloro-4-methoxyphenylacetic acid methyl ester;Benzeneacetic acid, 2-chloro-4-methoxy-, methyl ester
• CAS NO: 847604-18-6
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.65
• Mol File: 847604-18-6.mol

Chemical Properties

• Boiling Point: 286.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-chloro-4-methoxyphenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-methoxyphenylacetic acid methyl ester(847604-18-6)
• EPA Substance Registry System: 2-chloro-4-methoxyphenylacetic acid methyl ester(847604-18-6)

Safety Data

• Hazardous Substances Data: 847604-18-6(Hazardous Substances Data)

Upstream product

• 4021-11-8 2-methylisonicotinic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 91367-09-8 2-(2-chloro-4-methoxyphenyl)acetic acid 
• 67-56-1 methanol 
• 170737-93-6 2-chloro-4-methoxyphenylacetonitrile 

Downstream Products

• 72766-07-5 (2-chloro-4-hydroxy-phenyl)-acetic acid methyl ester 
• 1246685-54-0 6-[2-(2-chloro-4-methoxy-phenyl)-acetyl]-7-fluoro-4-methyl-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

Intramolecular palladium-catalyzed alkane C-H arylation from aryl chlorides

The first examples of efficient and general palladium-catalyzed intramolecular C(sp3)-H arylation of (hetero)aryl chlorides, giving rise to a variety of valuable cyclobutarenes, indanes, indolines, dihydrobenzofurans, and indanones, are described. The use of aryl and heteroaryl chlorides significantly improves the scope of C(sp3)-H arylation by facilitating the preparation of reaction substrates. Careful optimization studies have shown that the palladium ligand and the base/solvent combination are crucial to obtaining the desired class of product in high yields. Overall, three sets of reaction conditions employing PtBu3, PCyp3, or PCy3 as the palladium ligand and K 2CO3/DMF or Cs2CO3/pivalic acid/mesitylene as the base/solvent combination allowed five different classes of products to be accessed using this methodology. In total, more than 40 examples of C-H arylation have been performed successfully. When several types of C(sp3)-H bond were present in the substrate, the arylation was found to occur regioselectively at primary C-H bonds vs secondary or tertiary positions. In addition, in the presence of several primary C-H bonds, selectivity trends correlate with the size of the palladacyclic intermediate, with five-membered rings being favored over six- and seven-membered rings. Regio- and diastereoselectivity issues were studied computationally in the prototypal case of indane formation. DFT(B3PW91) calculations demonstrated that C-H activation is the rate-determining step and that the creation of a C-H agostic interaction, increasing the acidity of a geminal C-H bond, is a critical factor for the regiochemistry control.

1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS

The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

THIENOPYRIDINE-PHENYLACET AMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS

The invention relates to compounds represented by Formula (I):, and to prodrugs thereof, pharmaceutically salts or solvates of said compounds or said prodrugs, wherein each of X1-X5 and R1-R5 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).