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847608-28-0

4,5,6-Trichloronicotinic acid is a chemical compound with the formula C6H2Cl3NO2. It is a trichlorinated derivative of nicotinic acid, which is a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD).
Used in Pharmaceutical Industry:
4,5,6-Trichloronicotinic acid is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs.
Used in Agrochemical Industry:
4,5,6-Trichloronicotinic acid is used as an intermediate in the synthesis of agrochemicals, contributing to the creation of products for agricultural applications.
Used as a Herbicide:
4,5,6-Trichloronicotinic acid has been studied for its potential as a herbicide, indicating its possible use in controlling, preventing, or killing unwanted plants.
Used as an Insecticide:
4,5,6-Trichloronicotinic acid has also been studied for its potential as an insecticide, suggesting its possible application in managing and controlling insect populations.
Safety and Handling:
4,5,6-Trichloronicotinic acid is considered to be moderately hazardous, and it is crucial to take proper safety precautions when handling it. Additionally, adherence to local regulations and guidelines for its use and disposal is essential to ensure environmental and personal safety.

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  • 847608-28-0 Structure

  • Basic information

    1. Product Name: 4,5,6-Trichloronicotinic acid
    2. Synonyms: 4,5,6-Trichloronicotinic acid;4,5,6-Trichloropyridine-3-carboxylic acid
    3. CAS NO:847608-28-0
    4. Molecular Formula: C6H2Cl3NO2
    5. Molecular Weight: 226.44
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 847608-28-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4,5,6-Trichloronicotinic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4,5,6-Trichloronicotinic acid(847608-28-0)
    11. EPA Substance Registry System: 4,5,6-Trichloronicotinic acid(847608-28-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 847608-28-0(Hazardous Substances Data)

847608-28-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 847608-28-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,6,0 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 847608-28:
(8*8)+(7*4)+(6*7)+(5*6)+(4*0)+(3*8)+(2*2)+(1*8)=200
200 % 10 = 0
So 847608-28-0 is a valid CAS Registry Number.

847608-28-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5,6-trichloropyridine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 3-Pyridinecarboxylic acid,4,5,6-trichloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:847608-28-0 SDS

847608-28-0Relevant articles and documents

Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1h)-ones

Wallace, Eli M.,Lyssikatos, Joseph,Blake, James F.,Seo, Jeongbeob,Yang, Hong Woon,Yeh, Tammie C.,Perrier, Michele,Jarski, Heidi,Marsh, Vivienne,Poch, Gregory,Livingston, Michelle Goyette,Otten, Jennifer,Hingorani, Gary,Woessner, Rich,Lee, Patrice,Winkler, James,Koch, Kevin

, p. 441 - 444 (2007/10/03)

The role of MEK 1,2 in cancer tumorgenesis has been clearly demonstrated preclinically, and two selective inhibitors are currently undergoing clinical evaluation to determine their role in the human disease. We have discovered 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones as a new class of ATP noncompetitive MEK inhibitors. These inhibitors exhibit excellent cellular potency and good pharmacokinetic properties and have demonstrated the ability to inhibit ERK phosphorylation in HT-29 tumors from mouse xenograft studies.

Heterocyclic inhibitors of MEK and methods of use thereof

-

, (2008/06/13)

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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