846541-71-7

Basic information

• Product Name: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester
• Synonyms: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester;5-Chloro-4,6-dihydroxypyridine-3-carboxylic acid ethyl ester;5-Chloro-4-hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester
• CAS NO: 846541-71-7
• Molecular Formula: C₈H₈ClNO₄
• Molecular Weight: 217.60642
• Product Categories: Pyridines
• Mol File: 846541-71-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 2.05E-05mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(846541-71-7)
• EPA Substance Registry System: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(846541-71-7)

Safety Data

• Hazardous Substances Data: 846541-71-7(Hazardous Substances Data)

Usage

General Description

5-Chloro-4,6-dihydroxynicotinic acid ethyl ester is a chemical compound that belongs to the class of organic compounds known as pyridine carboxylic acids. It is derived from nicotinic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its diverse applications, including its use as a building block in the production of various drugs and pesticides. Its properties and structure make it an important component for the development of new compounds with potential therapeutic and agricultural benefits.

InChI:InChI=1/C8H8ClNO4/c1-2-14-8(13)4-3-10-7(12)5(9)6(4)11/h3H,2H2,1H3,(H2,10,11,12)

Upstream product

• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 

Downstream Products

• 181261-73-4 ethyl 4,5,6-trichloronicotinate 
• 847608-28-0 4,5,6-trichloronicotinic acid 
• 874353-12-5 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinic acid 
• 847373-08-4 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinic acid 
• 874353-11-4 methyl 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinate 
• 847373-09-5 methyl 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinate 

Relevant articles and documents

Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1h)-ones

The role of MEK 1,2 in cancer tumorgenesis has been clearly demonstrated preclinically, and two selective inhibitors are currently undergoing clinical evaluation to determine their role in the human disease. We have discovered 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones as a new class of ATP noncompetitive MEK inhibitors. These inhibitors exhibit excellent cellular potency and good pharmacokinetic properties and have demonstrated the ability to inhibit ERK phosphorylation in HT-29 tumors from mouse xenograft studies.