846541-71-7

Basic information

• Product Name: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester
• Synonyms: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester;5-Chloro-4,6-dihydroxypyridine-3-carboxylic acid ethyl ester;5-Chloro-4-hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester
• CAS NO: 846541-71-7
• Molecular Formula: C₈H₈ClNO₄
• Molecular Weight: 217.60642
• Product Categories: Pyridines
• Mol File: 846541-71-7.mol

Chemical Properties

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 2.05E-05mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(846541-71-7)
• EPA Substance Registry System: 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester(846541-71-7)

Safety Data

• Hazardous Substances Data: 846541-71-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-4,6-dihydroxynicotinic acid ethyl ester is used as a key intermediate in the synthesis of various drugs. Its unique structure allows for the development of new compounds with potential therapeutic benefits, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester serves as an essential building block in the production of pesticides. Its incorporation into these compounds helps enhance their effectiveness in protecting crops and managing pests, thereby supporting agricultural productivity and food security.
Used as a Research Compound:
5-Chloro-4,6-dihydroxynicotinic acid ethyl ester is also utilized in research and development, where it aids scientists in understanding the properties and behavior of pyridine carboxylic acids. Its role in the synthesis of new compounds and the exploration of their potential applications further expands the horizons of scientific knowledge and innovation.

InChI:InChI=1/C8H8ClNO4/c1-2-14-8(13)4-3-10-7(12)5(9)6(4)11/h3H,2H2,1H3,(H2,10,11,12)

Upstream product

• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 

Downstream Products

• 847608-28-0 4,5,6-trichloronicotinic acid 
• 874353-12-5 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinic acid 
• 847373-08-4 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinic acid 
• 874353-11-4 methyl 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinate 
• 847373-09-5 methyl 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinate 
• 181261-73-4 ethyl 4,5,6-trichloronicotinate 

Relevant articles and documents

Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1h)-ones

The role of MEK 1,2 in cancer tumorgenesis has been clearly demonstrated preclinically, and two selective inhibitors are currently undergoing clinical evaluation to determine their role in the human disease. We have discovered 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones as a new class of ATP noncompetitive MEK inhibitors. These inhibitors exhibit excellent cellular potency and good pharmacokinetic properties and have demonstrated the ability to inhibit ERK phosphorylation in HT-29 tumors from mouse xenograft studies.