848142-08-5

Basic information

• Product Name: N-(2-amino-3-pyridinyl)-N-(4-methoxybenzylidene)amine
• Synonyms: N-(2-amino-3-pyridinyl)-N-(4-methoxybenzylidene)amine
• CAS NO: 848142-08-5
• Molecular Formula: C13H13N3O
• Molecular Weight: 227.26182
• Mol File: 848142-08-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-amino-3-pyridinyl)-N-(4-methoxybenzylidene)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-amino-3-pyridinyl)-N-(4-methoxybenzylidene)amine(848142-08-5)
• EPA Substance Registry System: N-(2-amino-3-pyridinyl)-N-(4-methoxybenzylidene)amine(848142-08-5)

Safety Data

• Hazardous Substances Data: 848142-08-5(Hazardous Substances Data)

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Synthesis and antiproliferative activity in vitro of new 2-thioxoimidazo[4,5-b]pyridine derivatives

Two series of 2-thioxoimidazo[4,5-b]pyridine derivatives have been synthesized from 2,3-diaminopyridine (1) and 5-halogenosubstituted-2,3-diaminopyridines 2, 3. Mannich bases 7 - 12 and 24 - 29, derivatives of 1-arylamino-6-halogeno-2-thioxoimidazo[4,5-b]pyridine were obtained with selected secondary amines: morpholine, piperidine, 2-methoxyphenylpiperazine, pyrimidyn-2-yl-piperazine and formaldehyde in ethanol. The structures 7 - 12 and 24 - 29 were confirmed by the results of elementary analysis and their IR,1H-NMR and MS spectra. All given structures 7 - 12 have been optimized to get the most stable low energy conformers. Synthesized compounds were of interest for biological studies or can be substrates for further synthesis. The selected compounds 7 - 10, 12 - 17, 22, 25, 27 - 29 were screened for their antiproliferative activity in vitro against human cancer and normal mouse fibroblast cell lines.