849035-91-2

Basic information

• Product Name: 1-BOC-4-[4-(METHYLSULFONYL)-2-NITROPHENYL]PIPERIDIN-4-AMINE
• Synonyms: tert-Butyl4-[[4-(methylsulfonyl)-2-nitrophenyl]amino]piperidine-1-carboxylate; tert-Butyl4-[[4-(methylsulfonyl)-3-nitrophenyl]amino]piperidine-1-carboxylate
• CAS NO: 849035-91-2
• Molecular Formula: C₁₇H₂₅N₃O₆S
• Molecular Weight: 399.47
• Mol File: 849035-91-2.mol

Chemical Properties

• Boiling Point: 576.7°C at 760 mmHg
• Flash Point: 302.6°C
• Appearance: /
• Density: 1.317g/cm³
• Vapor Pressure: 2.66E-13mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 1-BOC-4-[4-(METHYLSULFONYL)-2-NITROPHENYL]PIPERIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-[4-(METHYLSULFONYL)-2-NITROPHENYL]PIPERIDIN-4-AMINE(849035-91-2)
• EPA Substance Registry System: 1-BOC-4-[4-(METHYLSULFONYL)-2-NITROPHENYL]PIPERIDIN-4-AMINE(849035-91-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 849035-91-2(Hazardous Substances Data)

Usage

Chemical class

Piperidine derivative

Structural features

BOC-protected amino group
Piperidine ring
Methylsulfonyl group at the 4th position
Nitrophenyl group at the 4th position

Potential applications

Medicinal chemistry and pharmaceutical research

Biological activities

Unknown, but may have potential due to structural features

Safety precautions

Handle and use with caution, as it may pose risks if not handled properly

Molecular weight

Approximately 350.43 g/mol

Appearance

Likely a solid, but specific appearance not provided

Solubility

Unknown, but may vary depending on solvent

Stability

Unknown, but stability may be affected by factors such as temperature, light, and humidity

Reactivity

Unknown, but may react with certain chemicals, such as acids, bases, or reducing agents

Storage

Should be stored in a cool, dry place, away from direct sunlight and moisture

Disposal

Dispose of according to local regulations and safety guidelines for hazardous chemicals

Synonyms

None provided, but may have alternative names or trade names in the chemical industry

Purity

Not specified, but purity may vary depending on the synthesis method and purification techniques used

Synthesis

Not provided, but the compound can likely be synthesized through various chemical reactions involving piperidine and other starting materials

Analytical methods

Not specified, but techniques such as NMR, mass spectrometry, and elemental analysis may be used to characterize the compound

Regulatory status

Not specified, but may be subject to regulations depending on the intended use and location

Environmental impact

Not provided, but the compound may have potential environmental effects if released into the environment
Please note that some information, such as appearance, solubility, stability, reactivity, and environmental impact, is not provided in the material and may require further research or experimentation to determine.

InChI:InChI=1/C17H25N3O6S/c1-17(2,3)26-16(21)19-9-7-12(8-10-19)18-14-6-5-13(27(4,24)25)11-15(14)20(22)23/h5-6,11-12,18H,7-10H2,1-4H3

Upstream product

• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 

Downstream Products

• 1037835-06-5 1-{1-[2-(4-trifluoromethylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-07-6 1-{1-[2-(4-tert-butylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-10-1 1-{1-[2-(4-methoxy-4-methylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-08-7 1-{1-[2-(4-isopropylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-04-3 1-{1-[2-(4-methoxycyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-11-2 1-{1-[2-(1-methylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-03-2 1-[1-(2-(4-methylcyclohexyl)-2-oxoethyl)piperidin-4-yl]-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037835-01-0 1-[1-(2-cyclohexyl-2-oxoethyl)piperidin-4-yl]-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037834-94-8 tert-butyl 4-{[2-amino-4-(methylsulfonyl)phenyl]amino}piperidine-1-carboxylate 

Relevant articles and documents

Imidazole derivative and application thereof as TRPV4 inhibitor

The invention relates to imidazole derivatives of formula (I) and pharmaceutically acceptable salts, isomers, prodrugs and pharmaceutical compositions thereof. The compounds are inhibitors of vanilloid 4 type transient receptor potential channels (TRPV4).

INHIBITORS OF SERINE PALMITOYLTRANSFERASE

This invention provides compounds of the formula (I) useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).