455-15-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluorophenyl methyl sulfone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
1. Preparation of Substituted Indazole Amides:
In the pharmaceutical industry, 4-Fluorophenyl methyl sulfone is used as a starting material for the preparation of substituted indazole amides. These compounds serve as glucokinase activators, which play a crucial role in regulating blood glucose levels and have potential applications in the treatment of type 2 diabetes.
2. Synthesis of 4-(4′-Trifluoromethoxyphenoxy)Phenyl Methyl Sulfone:
Another application of 4-Fluorophenyl methyl sulfone in the pharmaceutical industry is its use in the preparation of 4-(4′-trifluoromethoxyphenoxy)phenyl methyl sulfone. 4-FLUOROPHENYL METHYL SULFONE has potential applications in the development of new drugs targeting various diseases and conditions.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 371-15-3 p-fluorothioanisole 
• 124-63-0 methanesulfonyl chloride 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 14101-14-5 (4-fluorophenyl)trimethyltin 
• 33599-22-3 (4-methanesulfonylphenyl)-N,N-dimethyl-amine 
• 153435-39-3 1-methanesulfonyl-4-(tributylstannyl)benzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 67-68-5 dimethyl sulfoxide 
• 62696-04-2 TBHP 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 110-05-4 di-tert-butyl peroxide 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 512-56-1 trimethyl phosphite 

Downstream Products

• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 99902-90-6 4-(4'-methylphenyloxy)-phenyl methyl sulfone 
• 99902-91-7 C₁₃H₁₁ClO₃S 
• 99902-92-8 C₁₃H₁₁ClO₃S 
• 75259-44-8 1-(4-Fluoro-benzenesulfonylmethyl)-cyclohexanol 
• 75259-28-8 1-(4-Chloro-phenyl)-2-(4-fluoro-benzenesulfonyl)-ethanol 
• 75259-41-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-ol 
• 75259-43-7 1-(4-Fluoro-benzenesulfonyl)-propan-2-ol 
• 75259-42-6 1-(4-Fluoro-benzenesulfonyl)-2-methyl-butan-2-ol 
• 286844-91-5 1-(methylsulfonyl)-4-(4'-(trifluoromethoxy)phenoxy)benzene 
• 90357-06-5 Bicalutamide 
• 228578-04-9 4-(4'-methylsulfonyl)phenoxyphenyl allyl ether 

Relevant academic research and scientific papers

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Sulfoxide and Sulfone Synthesis via Electrochemical Oxidation of Sulfides

The oxidation of diaryl sulfides and aryl alkyl sulfides to the corresponding sulfoxides and sulfones under electrochemical conditions is reported. Sulfoxides are selectively obtained in good yield under a constant current of 5 mA for 10 h in DMF, while sulfones are formed as the major product under a constant current of 10 or 20 mA for 10 h in MeOH. The oxygen of both the sulfoxide and sulfone function is derived from water.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is

Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides toN-cyanosulfoximines has been developed. In total, 69 examples of sulfoxides, sulfones, andN-cyanosulfoximines have been synthesized in good to excellent yields and with high current efficiencies. The synthesis was assisted and facilitated through a supporting electrolyte-free, fully automated electrochemical protocol that highlights the advantages of flow electrolysis.

PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF

The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

COVALENT ORGANIC FRAMEWORKS AND APPLICATIONS AS PHOTOCATALYSTS

Described herein are covalent organic frameworks. The covalent organic frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses. In one aspect, the covalent organic frameworks are composed of a plurality of fused aromatic groups and electron-deficient chromophores. The covalent organic frameworks are useful as photocatalysts in a number of different applications.

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

Deoxyfluorination of alcohols with aryl fluorosulfonates

Aryl fluorosulfonates are developed as a deoxyfluorinating reagent in the transformation of primary and secondary alcohols into the corresponding alkyl fluorides. These reagents feature easy availability, low-cost, high stability and high efficiency. Diverse functionalities including aldehyde, ketone, ester, halogen, nitro, alkene, and alkyne are well tolerated under mild reaction conditions.