455-15-2

Basic information

• Product Name: 4-FLUOROPHENYL METHYL SULFONE
• Synonyms: Sulfone, p-fluorophenyl methyl;4-FLUOROPHENYL METHYL SULPHONE;4-FLUOROPHENYL METHYL SULFONE;1-FLUORO-4-(METHYLSULFONYL)BENZENE;1-fluoro-4-(methylsulphonyl)benzene;4-Fluorophenylmethylsulfone,97%;4-Fluorobenzenesulfinic Acid Methyl Este;4-Fluorophenyl
• CAS NO: 455-15-2
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.19
• EINECS: 207-237-0
• Product Categories: Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 455-15-2.mol
• Article Data: 73

Chemical Properties

• Melting Point: 78-81 °C(lit.)
• Boiling Point: 95-97°C 7mm
• Flash Point: 132.8 °C
• Appearance: Almost white/Adhering Crystalline Powder
• Density: 1.2768 (estimate)
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
• BRN: 2045674
• CAS DataBase Reference: 4-FLUOROPHENYL METHYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)
• EPA Substance Registry System: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-15-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 455-15-2 differently. You can refer to the following data:
1. 4-Fluorophenyl methyl sulfone is used for preparation of substituted indazole amides as glucokinase activators.
2. 4-Fluorophenyl methyl sulfone was used in the preparation of 4-(4′-trifluoromethoxyphenoxy)phenyl methyl sulfone.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 371-15-3 p-fluorothioanisole 
• 124-63-0 methanesulfonyl chloride 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 14101-14-5 (4-fluorophenyl)trimethyltin 
• 371-42-6 4-Fluorothiophenol 
• 1765-93-1 4-fluoroboronic acid 
• 20277-69-4 sodium methansulfinate 
• 110-05-4 di-tert-butyl peroxide 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 74-88-4 methyl iodide 
• 402-46-0 4-fluorophenylsulphonamide 
• 67-56-1 methanol 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 99902-90-6 4-(4'-methylphenyloxy)-phenyl methyl sulfone 
• 99902-91-7 C₁₃H₁₁ClO₃S 
• 99902-92-8 C₁₃H₁₁ClO₃S 
• 75259-28-8 1-(4-Chloro-phenyl)-2-(4-fluoro-benzenesulfonyl)-ethanol 
• 75259-41-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-ol 
• 75259-42-6 1-(4-Fluoro-benzenesulfonyl)-2-methyl-butan-2-ol 
• 286844-91-5 1-(methylsulfonyl)-4-(4'-(trifluoromethoxy)phenoxy)benzene 
• 90357-06-5 Bicalutamide 

Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

Sulfoxide and Sulfone Synthesis via Electrochemical Oxidation of Sulfides

The oxidation of diaryl sulfides and aryl alkyl sulfides to the corresponding sulfoxides and sulfones under electrochemical conditions is reported. Sulfoxides are selectively obtained in good yield under a constant current of 5 mA for 10 h in DMF, while sulfones are formed as the major product under a constant current of 10 or 20 mA for 10 h in MeOH. The oxygen of both the sulfoxide and sulfone function is derived from water.