849509-52-0

Basic information

• Product Name: 3-bromo-4-ethoxy-N-[4-(hydroxymethyl)phenyl]benzamide
• CAS NO: 849509-52-0
• Molecular Formula: C₁₆H₁₆BrNO₃
• Molecular Weight: 350.20714
• Mol File: 849509-52-0.mol

Chemical Properties

• CAS DataBase Reference: 3-bromo-4-ethoxy-N-[4-(hydroxymethyl)phenyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-4-ethoxy-N-[4-(hydroxymethyl)phenyl]benzamide(849509-52-0)
• EPA Substance Registry System: 3-bromo-4-ethoxy-N-[4-(hydroxymethyl)phenyl]benzamide(849509-52-0)

Safety Data

• Hazardous Substances Data: 849509-52-0(Hazardous Substances Data)

Upstream product

• 623-04-1 4-aminobenzenemethanol 
• 24507-30-0 3-bromo-4-ethoxybenzoyl chloride 

Downstream Products

• 849509-54-2 3-bromo-4-ethoxy-N-(4-formyl-phenyl)-benzamide 

Relevant articles and documents

N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors

A novel class of N-(4-{[4-(1H-benzoimidazol-2-yl)-arylamino]-methyl}- phenyl)-benzamides are described as inhibitors of the endo-β-glucuronidase heparanase. Among them are N-(4-{[4-(1H-benzoimidazol-2-yl)-phenylamino]-methyl} -phenyl)-3-bromo-4-methoxy-benzamide (15h), and N-(4-{[5-(1H-benzoimidazol-2-yl) -pyridin-2-ylamino]-methyl}- phenyl)-3-bromo-4-methoxy-benzamide (23) which displayed good heparanase inhibitory activity (IC50 0.23-0.29 μM), with the latter showing oral exposure in mice.

ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY

The present invention encompasses heparanase inhibitors, particularly to certain 2-substituted heteroaryl-fused and aryl-fused carbazole derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the co