849659-29-6

Basic information

• Product Name: ethyl 2-amino-4-(2-methoxyphenyl)thiophene-3-carboxylate
• Synonyms: ethyl 2-amino-4-(2-methoxyphenyl)thiophene-3-carboxylate
• CAS NO: 849659-29-6
• Molecular Formula: C₁₄H₁₅NO₃S
• Molecular Weight: 277.3388
• Mol File: 849659-29-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-amino-4-(2-methoxyphenyl)thiophene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-4-(2-methoxyphenyl)thiophene-3-carboxylate(849659-29-6)
• EPA Substance Registry System: ethyl 2-amino-4-(2-methoxyphenyl)thiophene-3-carboxylate(849659-29-6)

Safety Data

• Hazardous Substances Data: 849659-29-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 21769-00-6 2-cyano-3-(2-methoxyphenyl)-but-2-enoic acid ethyl ester 
• 579-74-8 2-Methoxyacetophenone 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1101067-78-0 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(2-methoxyphenyl)-thiophene-3-carboxylic acid ethyl ester 
• 1437773-96-0 2-cyclopropyl-5-(2-methoxyphenyl)-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine 
• 1437774-76-9 4-chloro-2-cyclopropyl-5-(2-methoxyphenyl)thieno[2,3-d]pyrimidine 
• 935760-41-1 ethyl 5-(2-methoxyphenyl)-4-oxo-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxylate 
• 935759-54-9 5-(2-methoxyphenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 851853-09-3 [5-[2-(3-diethylaminopropoxy)phenyl]-3-(3-fluorophenyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester 
• 851853-07-1 [3-(3-fluorophenyl)-5-(2-methoxyphenyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester 
• 851853-08-2 [3-(3-fluorophenyl)-5-(2-hydroxyphenyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester 
• 851852-98-7 3-(3-fluorophenyl)-2-mercapto-5-(2-methoxyphenyl)-3H-thieno[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Discovery of novel, highly potent, and selective matrix metalloproteinase (MMP)-13 inhibitors with a 1,2,4-triazol-3-yl moiety as a zinc binding group using a structure-based design approach

On the basis of a superposition study of X-ray crystal structures of complexes of quinazoline derivative 1 and triazole derivative 2 with matrix metalloproteinase (MMP)-13 catalytic domain, a novel series of fused pyrimidine compounds which possess a 1,2,4-triazol-3-yl group as a zinc binding group (ZBG) was designed. Among the herein described and evaluated compounds, 31f exhibited excellent potency for MMP-13 (IC50 = 0.036 nM) and selectivities (greater than 1,500-fold) over other MMPs (MMP-1, -2, -3, -7, -8, -9, -10, and -14) and tumor necrosis factor-α converting enzyme (TACE). Furthermore, the inhibitor was shown to protect bovine nasal cartilage explants against degradation induced by interleukin-1 and oncostatin M. In this article, we report the discovery of extremely potent, highly selective, and orally bioavailable fused pyrimidine derivatives that possess a 1,2,4-triazol-3-yl group as a novel ZBG for selective MMP-13 inhibition.

HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF

The present invention provides a novel amide compound represented by the following formula, which has a matrix metalloproteinase inhibitory activity and is useful as a pharmaceutical agent. wherein each symbol is as defined in the specification.

SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS

The present invention provides novel compounds and methods useful for treating transglutaminase associated disorders such as celiac spru, Alzheimer's disease and Huntington's disease. Certain compounds of the invention are tissue transglutaminase inhibito

Structure-activity relationship study of novel tissue transglutaminase inhibitors

Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative

Pharmaceutically active compounds and methods of use

New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of neuropathic pain.