851853-07-1Relevant articles and documents
SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS
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Page/Page column 72-73; 78-79, (2010/11/08)
The present invention provides novel compounds and methods useful for treating transglutaminase associated disorders such as celiac spru, Alzheimer's disease and Huntington's disease. Certain compounds of the invention are tissue transglutaminase inhibito
Structure-activity relationship study of novel tissue transglutaminase inhibitors
Duval, Eric,Case, April,Stein, Ross L.,Cuny, Gregory D.
, p. 1885 - 1889 (2007/10/03)
Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative