850352-43-1

Basic information

• Product Name: 2-BroMo-1-(2-naphthalenyl)-1-pentanone
• Synonyms: 2-BroMo-1-(2-naphthalenyl)-1-pentanone;2-BroMo-1-(naphthalen-2-yl)-1-pentanone;2-broMo-1-(naphthalen-2-yl)pentan-1-one
• CAS NO: 850352-43-1
• Molecular Formula: C15H15BrO
• Molecular Weight: 291
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 850352-43-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ethanol, Methanol
• CAS DataBase Reference: 2-BroMo-1-(2-naphthalenyl)-1-pentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-1-(2-naphthalenyl)-1-pentanone(850352-43-1)
• EPA Substance Registry System: 2-BroMo-1-(2-naphthalenyl)-1-pentanone(850352-43-1)

Safety Data

• Hazardous Substances Data: 850352-43-1(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Solid

Upstream product

• 613-46-7 2-naphthalenecarbonitrile 
• 33489-63-3 1-naphthalen-2-yl-pentan-1-one 

Relevant articles and documents

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: A promising class of monoamine uptake inhibitors

Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction at monoamine receptors has profound effects upon a multitude of pharmacological outcomes. Our interest has focused on neurotransmitter reuptake mechanisms in a search for medications for cocaine abuse. Herein we describe the synthesis and biological evaluation of an array of 2-aminopentanophenones. This array has yielded selective inhibitors of the dopamine and norepinephrine transporters with little effect upon serotonin trafficking. A subset of compounds had no significant affinity at 5HT1A, 5HT1B, 5HT1C, D1, D2, or D3 receptors. The lead compound, racemic 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one 4a, was resolved into its enantiomers and the S isomer was found to be the most biologically active enantiomer. Among the most potent of these DAT/NET selective compounds are the 1-(3,4-dichlorophenyl)- (4u) and the 1-naphthyl- (4t) 2-pyrrolidin-1-yl-pentan-1-one analogues.

PYROVALERONE ANALOGS AND THERAPEUTIC USES THEREOF

New compounds that bind to monoamine transporters are described. The compounds of the present invention can be racemic or pure R-or S-enantiomers. Certain preferred compounds of the present invention have a high selectively dopamine transporter versus the serotonin transporter. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.