33489-63-3

Usage

Uses

Used in Perfumery Industry:
Butyl 2-naphthyl ketone is used as a fixative in perfumes for its ability to slow down the evaporation rate of fragrances, thus enhancing their longevity. Its strong musky aroma, similar to the natural scent of musk, makes it a valuable ingredient in creating long-lasting scents.
Used in Fragrance Industry:
In the fragrance industry, Butyl 2-naphthyl ketone is used as a key component in the formulation of various scents. Its musky aroma contributes to the depth and complexity of fragrances, providing a rich and lasting olfactory experience.
Used in Cosmetics Industry:
Butyl 2-naphthyl ketone is also used in the cosmetics industry, where it serves as a fixative in the formulation of scented products such as body lotions, creams, and deodorants. Its ability to prolong the scent of these products makes it a valuable addition to cosmetic formulations.
Used in Environmentally Friendly Alternatives:
Due to the restrictions on the use of Butyl 2-naphthyl ketone in Western nations, there is a growing interest in developing environmentally friendly alternatives. These alternatives aim to replicate the musky aroma and fixative properties of Butyl 2-naphthyl ketone without the associated environmental risks.

Upstream product

• 109-72-8 n-butyllithium 
• 66-99-9 β-naphthaldehyde 
• 93-09-4 naphthalene-2-carboxylate 
• 91-20-3 naphthalene 
• 109057-50-3 Pentaneselenoic acid Se-phenyl ester 
• 638-29-9 n-valeryl chloride 
• 638210-60-3 1-(naphthalen-2-yl)pent-4-en-1-ol 
• 131780-17-1 1-(naphthalen-2-yl)pent-4-en-1-one 
• 789-25-3 HSiPh₃ 
• 496835-91-7 4-bromonaphthalene-2-carbonitrile 
• 124-38-9 carbon dioxide 

Downstream Products

• 850352-43-1 2-bromo-1-naphthalen-2-yl-pentan-1-one 
• 850352-53-3 naphyrone 

Relevant academic research and scientific papers

Nickel-catalyzed remote hydrosilylation of unconjugated enones with bulky triphenylsilane

Herein we describe a nickel-catalyzed remote hydrosilylation of unconjugated enones with bulky triphenylsilane. A range ofZ-silyl enol ethers are obtained as major isomers due to the process of nickel triggered alkene isomerization. Notably, some specific

P -Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis

p-Selective (sp2)-C-H functionalization of electron rich arenes has been achieved for acylation and alkylation reactions, respectively, with acyl/alkylselenides by organic photoredox catalysis involving an interesting mechanistic pathway.

Highly chemoselective and versatile method for direct conversion of carboxylic acids to ketones utilizing zinc Ate complexes

Various carboxylic acids were directly transformed into the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to the undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity. No need to overreact: Various carboxylic acids were directly transformed to the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity.

A new route for manufacture of 3-cyano-1-naphthalenecarboxylic acid

3-Cyano-1-naphthalenecarboxylic acid is an intermediate required for manufacture of tachykinin receptor antagonists. The 1,3-disubstitution pattern on the naphthalene skeleton complicates the synthesis of this cyano acid. Previous literature-based chemistry is unattractive for large-scale manufacture due to stoichiometric use of mercury salts, low yield, and other operational difficulties. An attractive new route has been developed by establishing the 1,3-substitution on the carbon atoms destined for only one-half of the naphthalene 2-ring system, via 3-bromocoumalate, and then building up the rest of the naphthalene ring system by Diels-Alder addition of 3-bromocoumalate to in situ-generated benzyne. The resulting 4-bromo-2-naphthoate was converted to the required cyanoacid by transformation of ester to nitrile followed by carbonylation of the bromo substituent. The new route has been scaled up successfully and offers significant advantages over previous literature chemistry in terms of improved process environmental implications, improved yield, lower cost, and improved robustness and ease of operation at larger scales of operation.

1,3-Dithiane polymers for the supported synthesis of ketones

The synthesis of polymeric reagents containing an odorless propane-1,3- dithiol functionality is reported. Their usefulness for the solid phase synthesis of ketones via the umpoled alkylation of 1,3-dithianes is demonstrated.