- ANTIMICROBIAL AGENTS
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The invention provides a compound of formula I:or a salt thereof, wherein R3-R8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
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Page/Page column 135-136
(2012/01/14)
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- Preparation of 1,4-dihydroquinolines bearing a chiral sulfoxide group: New highly enantioselective recyclable NADH mimics
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The stereoselective preparation of 1-,4-dihydroquinolines possessing a chiral sulfoxide group at C-3 is reported. These novel biomimetic NADH models (R)-1a,b have been shown to be highly enantioselective in the reduction of methyl benzoylformate, producing (R)-methyl mandelate in up to 95% ee. The corresponding quinolinium salts 4a,b have been recovered in good yields. The regenerated models 1a,b could be reused without any significant erosion of the enantioselectivity. Georg Thieme Verlag Stuttgart.
- Gaillard, Stéphane,Papamica?l, Cyril,Marsais, Francis,Dupas, Georges,Levacher, Vincent
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p. 441 - 444
(2007/10/03)
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