3-Bromo-6,7-dimethoxyquinoline

Base Information

• Chemical Name: 3-Bromo-6,7-dimethoxyquinoline
• CAS No.: 850352-73-7
• Molecular Formula: C11H10BrNO2
• Molecular Weight: 268.10700
• Mol file: 850352-73-7.mol

Synonyms:3-Bromo-6,7-dimethoxy-quinoline;6,7-dimethoxy-3-bromoquinoline;

Chemical Property of 3-Bromo-6,7-dimethoxyquinoline

Chemical Property:

• PSA: 31.35000
• LogP: 3.01450

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Bromo-6,7-dimethoxyquinoline

There total 5 articles about 3-Bromo-6,7-dimethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2-bromomalondialdehyde (19263-02-6) + 3,4-dimethoxyaniline (6315-89-5) → 3-bromo-6,7-dimethoxyquinoline (850352-73-7)

Guidance literature:

With hydrogenchloride; In ethanol; for 12h; Heating;

DOI:10.1055/s-2005-862350

Reference yield: 30.0%

2-bromoacrolein (14925-39-4) + 3,4-dimethoxyaniline (6315-89-5) → 3-bromo-6,7-dimethoxyquinoline (850352-73-7)

Guidance literature:

With bromine; acetic acid; for 1h; Heating;

DOI:10.1055/s-2005-862350

Reference yield: 29.0%

2-Bromo-malonaldehyde (2065-75-0) + 3,4-dimethoxyaniline (6315-89-5) → 3-bromo-6,7-dimethoxyquinoline (850352-73-7)

Guidance literature:

2-Bromo-malonaldehyde; 3,4-dimethoxyaniline; With hydrogenchloride; In ethanol; water; for 12h; Inert atmosphere; Reflux;

With sodium hydroxide; pH=9;

upstream raw materials:

2-bromoacrolein

3,4-dimethoxyaniline

2-bromomalondialdehyde

(6,7-dimethoxy-quinolin-3-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

C₃₄H₄₀NO₄⁽¹⁺⁾*I^(1-)

C₃₂H₃₆NO₄⁽¹⁺⁾*I^(1-)

C₃₁H₃₃NO₄

C₃₂H₃₈NO₄⁽¹⁺⁾*I^(1-)

Refernces

• 1、 Gaillard, Stéphane,Papamica?l, Cyril,Marsais, Francis,Dupas, Georges,Levacher, Vincent. "Preparation of 1,4-dihydroquinolines bearing a chiral sulfoxide group: New highly enantioselective recyclable NADH mimics". . p. 441 - 444. Retrieved 2007/10/03.