- Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD
-
Design and syntheses of a novel series of muscarinic antagonists are reported. These efforts have culminated in the discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide (4a) as a potent and pan-active musca
- Wan, Zehong,Laine, Dramane I.,Yan, Hongxing,Zhu, Chongjie,Widdowson, Katherine L.,Buckley, Peter T.,Burman, Miriam,Foley, James J.,Sarau, Henry M.,Schmidt, Dulcie B.,Webb, Edward F.,Belmonte, Kristen E.,Palovich, Michael
-
scheme or table
p. 4560 - 4562
(2010/04/24)
-
- Design, synthesis, and structure - Activity relationship of tropane muscarinic acetylcholine receptor antagonists
-
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure - activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very pot
- Lainé, Dramane I.,Wan, Zehong,Yan, Hongxing,Zhu, Chongjie,Xie, Haibo,Fu, Wei,Busch-Petersen, Jakob,Neipp, Christopher,Davis, Roderick,Widdowson, Katherine L.,Blaney, Frank E.,Foley, James,Bacon, Alicia M.,Webb, Edward F.,Luttmann, Mark A.,Burman, Miriam,Sarau, Henry M.,Salmon, Michael,Palovich, Michael R.,Belmonte, Kristen
-
experimental part
p. 5241 - 5252
(2010/03/02)
-
- NOVEL COMBINATION OF THERAPEUTIC AGENTS
-
Novel combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist and/or a corticosteroid for inhaled administration via the nose or mouth, and methods of using them are provided herein.
- -
-
Page/Page column 16-17
(2009/04/25)
-
- Novel Formulations
-
A pharmaceutical aerosol formulation includes a therapeutically effective amount of particulate medicament of formula (I) or a solvate thereof, a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof, and a biocompatible polymer comprising one or more compounds of formula (II)
- -
-
-