850607-58-8Relevant articles and documents
Novel Formulations
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, (2009/05/28)
A pharmaceutical aerosol formulation includes a therapeutically effective amount of particulate medicament of formula (I) or a solvate thereof, a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof, and a biocompatible polymer comprising one or more compounds of formula (II)
Design, synthesis, and structure - Activity relationship of tropane muscarinic acetylcholine receptor antagonists
Lainé, Dramane I.,Wan, Zehong,Yan, Hongxing,Zhu, Chongjie,Xie, Haibo,Fu, Wei,Busch-Petersen, Jakob,Neipp, Christopher,Davis, Roderick,Widdowson, Katherine L.,Blaney, Frank E.,Foley, James,Bacon, Alicia M.,Webb, Edward F.,Luttmann, Mark A.,Burman, Miriam,Sarau, Henry M.,Salmon, Michael,Palovich, Michael R.,Belmonte, Kristen
experimental part, p. 5241 - 5252 (2010/03/02)
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure - activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very pot