85068-34-4

Basic information

• Product Name: 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE
• Synonyms: 3',5'-Bis(trifluoromethyl)propiophenone98%;3',5'-Bistrifluoromethylpropiophenonehenone;1-(3,5-Bis(trifluoroMethyl)phenyl)propan-1-one;3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE;3,5-BIS(TRIFLUOROMETHYL)PROPIOPHENONE;3,5-DI(TRIFLUOROMETHYL)PROPIOPHENONE;TIMTEC-BB SBB005962;1-[3,5-Bis(trifluoromethyl)phenyl]-1-propanone
• CAS NO: 85068-34-4
• Molecular Formula: C₁₁H₈F₆O
• Molecular Weight: 270.17
• EINECS: 285-296-1
• Mol File: 85068-34-4.mol

Chemical Properties

• Boiling Point: 72°C 7mm
• Flash Point: 169 °F
• Appearance: /
• Density: 1.379 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.705mmHg at 25°C
• Refractive Index: n20/D 1.4245(lit.)
• Storage Temp.: 2-8°C
• BRN: 7484754
• CAS DataBase Reference: 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE(85068-34-4)
• EPA Substance Registry System: 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE(85068-34-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 85068-34-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE is used as a building block for the synthesis of new pharmaceutical compounds due to its high level of fluorination. The presence of trifluoromethyl groups can enhance the lipophilicity, metabolic stability, and bioavailability of resulting drugs, making it a valuable component in the design of novel therapeutic agents.
Used in Agrochemical Development:
In the agrochemical industry, 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE is utilized as a starting material for the creation of new pesticides and herbicides. The introduction of fluorine atoms can improve the effectiveness and selectivity of these chemicals, leading to more efficient and environmentally friendly products.
Used in Organic Synthesis:
3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE serves as a versatile intermediate in organic synthesis. Its propiophenone core allows for a range of functionalization and modification reactions, making it suitable for the preparation of various organic compounds with potential applications in materials science, dyes, and other specialty chemicals.

InChI:InChI=1/C11H8F6O/c1-2-9(18)6-3-7(10(12,13)14)5-8(4-6)11(15,16)17/h3-5H,2H2,1H3

Upstream product

• 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde 
• 184888-50-4 1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol 

Downstream Products

• 184888-50-4 1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol 
• 1491168-98-9 N-(1-(3,5-bis(trifluoromethyl)phenyl)propyl)-N-((4-phenylpyridin-3-yl)methyl)furan-2-carboxamide 
• 1453069-77-6 C₁₂H₁₃F₆N 
• 1359871-77-4 (2-amino-4-(3,5-bis(trifluoromethyl)phenyl)-5-methylthiophen-3-yl)(4-chlorophenyl)methanone 
• 1359871-80-9 (2-amino-4-(3,5-bis(trifluoromethyl)phenyl)-5-methylthiophen-3-yl)(4-tolyl)methanone 
• 1359871-76-3 (2-amino-4-(3,5-bis(trifluoromethyl)phenyl)-5-methylthiophen-3-yl)(phenyl)methanone 
• 1359871-78-5 (2-amino-4-(3,5-bis(trifluoromethyl)phenyl)-5-methylthiophen-3-yl)(3,4-dichlorophenyl)methanone 
• 1359871-79-6 (2-amino-4-(3,5-bis(trifluoromethyl)phenyl)-5-methylthiophen-3-yl)(3-(trifluoromethyl)phenyl)methanone 
• 863976-10-7 DL-ethyl-3-hydroxy-3-[3',5'-bis(trifluoromethyl)phenyl]pentanoate 
• 620950-09-6 DL-2-hydroxy-2-[3',5'-bis(trifluoromethyl)phenyl]butyramide 
• 685503-45-1 1-[3,5-bis(trifluoromethyl)phenyl]propylamine 

Relevant articles and documents

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A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2nM.