- Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation
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Delivering cells using semi-permeable hydrogels is becoming an increasingly important direction in cell based therapies and regenerative medicine applications. Synthetic hydrogels have been functionalized with bioactive motifs to render otherwise inert po
- Lin, Chien-Chi,Boyer, Patrick D.,Aimetti, Alex A.,Anseth, Kristi S.
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Read Online
- Mobility of green fluorescent protein in hydrogel-based drug-delivery systems studied by anisotropy and fluorescence recovery after photobleaching
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Modified hydroxyethyl starch is photo-crosslinked in the presence of a green fluorescent protein (GFP) (mTagGFP) to obtain loaded hydrogels as model for a drug-delivery system. An important factor for the protein release is the crosslinking density since
- Bertz, Andreas,Ehlers, Jan-Eric,W?hl-Bruhn, Stefanie,Bunjes, Heike,Gericke, Karl-Heinz,Menzel, Henning
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Read Online
- A novel copper containing photoinitiator, copper(II) acylphosphinate, and its application in both the photomediated CuAAC reaction and in atom transfer radical polymerization
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A novel copper(ii) complex has been developed in which the counter anion, acylphosphinate, serves as a visible light photoinitiator. This molecule is inactive in the dark but, upon visible light exposure, both CuAAC and ATRP reactions are readily and rapi
- Gong, Tao,Adzima, Brian J.,Bowman, Christopher N.
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- Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications
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An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, we
- Levalley, Paige J.,Ovadia, Elisa M.,Bresette, Christopher A.,Sawicki, Lisa A.,Maverakis, Emanual,Bai, Shi,Kloxin, April M.
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- A HIGHLY FLOWABLE PREPOLYMER COMPOSITION OF HIGH RADIOPACITY ALLOWING FOR HIGH DEPTH PHOTOPOLYMERIZATION
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The invention relates to a highly flowable crosslinkable medical or dental composition comprising a crosslinkable compound, a polymerization initiator and a heterogeneous radiopacifier. Also described is a crosslinked polymer composition obtainable by crosslinking said highly flowable, crosslinkable medical or dental composition and the use of said highly flowable crosslinkable medical or dental composition to fill cavities or hollow structures in human or animal subjects.
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(2022/02/05)
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- Spatial Manipulation and Integration of Supramolecular Filaments on Hydrogel Substrates towards Advanced Soft Devices
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Supramolecular assemblies are promising building blocks for the fabrication of functional soft devices for high-tech applications. However, there is a lack of effective methods for large-scale manipulation and integration of nano-sized supramolecular stru
- Mendes, Eduardo,Oldenhof, Sander,Wang, Yiming,Zhang, Kai,van Esch, Jan H.
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supporting information
p. 8601 - 8607
(2020/03/30)
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- CONTACT-KILLING, QAC FUNCTIONALIZED THERMOPLASTIC POLYURETHANE FOR CATHETER APPLICATIONS
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In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.
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Paragraph 0268
(2019/04/25)
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- Preparation method, raw material, product and application of photo-crosslinking hydrogel material
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The invention provides a preparation method, a raw material, a product and an application of a photo-crosslinking hydrogel material. The preparation method comprises the steps of dissolving a component A, namely a photosensitive high polymer derivative, i
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Paragraph 0900-0902
(2019/06/07)
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- 3D IN VITRO MODELS OF LUNG TISSUE
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The invention relates to the discovery of tissue mimicking constructs and compositions that can be used to study the growth and development of cells in vitro. In certain embodiments, the invention provides methods of culturing cells on the tissue mimickin
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Page/Page column 45
(2019/07/20)
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- ANGIOGENIN-BORONIC ACID CONJUGATES WITH SELECTIVE NEUROPROTECTION ACTIVITY
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Masked h-ANG variant conjugates useful for protection of cells, particularly neuronal cells from injury and death, particularly from injury and death associated with ROS (reactive oxygen species). Masked h-Ang variant conjugates do not exhibit ribonucleolytic activity until unmasked. Masked h-ANG variant conjugates are activatable by reaction with ROS and exhibit ribonucleolytic activity only after reaction with ROS. Masked h-ANG variant conjugates are useful in the treatment of neurodegenerative diseases and disorders, such as amyotrophic lateral sclerosis. Certain h-ANG variants in which lysine at position 40 is replaced with cysteine are provided at least as starting materials for making masked h-ANG variant conjugates. Certain h-ANG variants in which lysine at position 40 is replaced with thialysine are generated on unmasking of h-ANG variant conjugates and exhibit ribonucleolyitc activity.
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(2018/07/29)
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- A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity
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Angiogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral sclerosis (ALS). ANG also promotes neovascularization, and can induce hemorrhage and encourage tumor growth. The causal neurodegeneration of ALS is associated with reactive oxygen species, which are also known to elicit the oxidative cleavage of carbon–boron bonds. We have developed a synthetic boronic acid mask that restrains the ribonucleolytic activity of ANG. The masked ANG does not stimulate endothelial cell proliferation but protects astrocytes from oxidative stress. By differentiating between the two dichotomous biological activities of ANG, this strategy could provide a viable pharmacological approach for the treatment of ALS.
- Hoang, Trish T.,Smith, Thomas P.,Raines, Ronald T.
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supporting information
p. 2619 - 2622
(2017/02/26)
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- CROSSLINKED POLY-DEPSIPEPTIDE COPOLYMERS AND METHODS OF MAKING THEREOF
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Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide
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Paragraph 0299
(2016/04/19)
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- Site-Specific Conjugation of Peptides and Proteins via Rebridging of Disulfide Bonds Using the Thiol-Yne Coupling Reaction
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(Figure Presented) Herein, we describe an extension of our previously reported photomediated disulfide rebridging methodology to the conjugation of peptides and proteins. The methodology proved to be reproducible with various alkynes and different peptide
- Griebenow, Nils,Dilma?, Alicia M.,Greven, Simone,Br?se, Stefan
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p. 911 - 917
(2016/05/19)
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- Three-dimensional fabrication of cell-laden biodegradable poly(ethylene glycol-co-depsipeptide) hydrogels by visible light stereolithography
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Stereolithography (SLA) holds great promise in the fabrication of cell-laden hydrogels with biomimetic complexity for use in tissue engineering and pharmaceutics. However, the availability of biodegradable photocrosslinkable hydrogel polymers for SLA is v
- Elomaa, Laura,Pan, Chi-Chun,Shanjani, Yaser,Malkovskiy, Andrey,Sepp?l?, Jukka V.,Yang, Yunzhi
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p. 8348 - 8358
(2015/11/09)
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- Stimuli-Responsive Supramolecular Hydrogels with High Extensibility and Fast Self-Healing via Precoordinated Mussel-Inspired Chemistry
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Supramolecular hydrogels have the advantages of stimuli responsiveness and self-healing compared to covalently cross-linked hydrogels. However, the existing supramolecular hydrogels are usually poor in mechanical properties, especially in extensibility. I
- Hou, Sen,Ma, Peter X.
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p. 7627 - 7635
(2015/12/01)
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- Macroporous 3-D scaffolds for tissue engineering
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Macroporous 3-D tissue engineering scaffold comprising elastomeric cross-linked polymer units and interconnected macropores containing living cells are produced by step of: in a mixture of the cells and elastomeric polymer units comprising activatable crosslinking groups, activating the crosslinking groups to form the scaffold.
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(2014/02/16)
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