- Preparation method of 5-bromo-2-chloro-7H-pyrrolo [2, 3-d] pyrimidine
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The invention discloses a preparation method of 5-bromo-2-chloro-7H-pyrrolo[2, 3-b] pyridine. According to the method, 2,4-chloro-7H-pyrrolo[2, 3-d] pyrimidine is used as a starting raw material, in the presence of zinc powder and acetic acid, selective d
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Paragraph 0046-0047
(2020/05/08)
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- PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives
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This paper describes a mild phenyliodine diacetate mediated method for selective chlorination, bromination, and iodination of indole C-H bonds using sodium halide as a source for analogous halogenations. The combination of NaX and phenyliodine diacetate provides an invincible system for halogenation of indoles. This protocol was compatible with a wide array of indole substrates and provides straight forward access to potential halogenated arenes.
- Himabindu, Vittam,Parvathaneni, Sai Prathima,Rao, Vaidya Jayathirtha
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p. 18889 - 18893
(2018/11/27)
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- Synthesis and biological activities of isogranulatimide analogues
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The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carci
- Hugon, Bernadette,Anizon, Fabrice,Bailly, Christian,Golsteyn, Roy M.,Pierre, Alain,Leonce, Stephane,Hickman, John,Pfeiffer, Bruno,Prudhomme, Michelle
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p. 5965 - 5980
(2008/03/15)
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- Synthesis of isogranulatimide analogues possessing a pyrrole moiety instead of an imidazole heterocycle
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An efficient four step synthesis from commercial indoles of isogranulatimide analogues is reported. In the new compounds, the imidazole moiety is replaced by a pyrrole unit, the indole part is substituted or not in 5-position and the nitrogen of the imide moiety bears or not a methyl substituent.
- Hugon, Bernadette,Pfeiffer, Bruno,Renard, Pierre,Prudhomme, Michelle
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p. 3927 - 3930
(2007/10/03)
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