- Photo-Induced ortho-C-H Borylation of Arenes through in Situ Generation of Rhodium(II) Ate Complexes
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Photoinduced in situ "oxidation"of half-sandwich metal complexes to "high-valent"cationic metal complexes has been used to accelerate catalytic reactions. Here, we report the unprecedented photoinduced in situ "reduction"of half-sandwich metal [Rh(III)] complexes to "low-valent"anionic metal [Rh(II)] ate complexes, which facilitate ligand exchange with electron-deficient elements (diboron). This strategy was realized by using a functionalized cyclopentadienyl (CpA3) Rh(III) catalyst we developed, which enabled the basic group-directed room temperature ortho-C-H borylation of arenes.
- Araujo Dias, Ant?nio Junio,Nagashima, Yuki,Tanaka, Jin,Tanaka, Ken
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supporting information
p. 11325 - 11331
(2021/08/03)
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- Microwave-Assisted Generation and Capture by Azoles of ortho-Quinone Methide Intermediates under Aqueous Conditions
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An efficient activator-free protocol for the coupling of o-hydroxybenzyl alcohols and azoles in water has been developed. This C–N bond-formation process is supposed to proceed through an ortho-quinone methide intermediate. A broad range of o-hydroxybenzy
- González-Pelayo, Silvia,López, Luis A.
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supporting information
p. 6003 - 6007
(2017/11/14)
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- Direct synthesis of pyrazolo[5,1-a]isoindoles via intramolecular palladium-catalyzed C-H bond activation
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An efficient, direct synthesis of pyrazolo-[5,1-a]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl) pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermolecular C-H bond activation.
- Choi, Young Lok,Lee, Hyuk,Kim, Bum Tae,Choi, Kihang,Heo, Jung-Nyoung
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supporting information; experimental part
p. 2041 - 2049
(2010/11/19)
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- Antiarrhytmic benzylimidazole
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Benzylazole derivatives being useful as antiarrhythmic agent are obtained by reacting the corresponding 2,3-epoxypropyloxybenzylazole with a primary or secondary amine.
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