A new chemical tool for exploring the physiological function of the PDE2 isozyme
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
Chambers, Robert J.,Abrams, Kristin,Garceau, Norman Y.,Kamath, Ajith V.,Manley, Christopher M.,Lilley, Susan C.,Otte, Douglas A.,Scott, Dennis O.,Sheils, Alissa L.,Tess, David A.,Vellekoop, A. Samuel,Zhang, Yan,Lam, Kelvin T.
p. 307 - 310
(2007/10/03)
OXINDOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE TYPE 2 INHIBITORS
The present invention provides compounds, methods and kits for treatment of disease states or disorders mediated by PDE2. Oxindole derivatives are provided which have therapeutic use and as PDE2 inhibitors.
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Page/Page column 15
(2008/06/13)
Tricyclic oxindole antiinflammatory agents
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents useful in the treatment of rheumatoid arthritis.
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(2008/06/13)
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