851682-14-9Relevant academic research and scientific papers
A new chemical tool for exploring the physiological function of the PDE2 isozyme
Chambers, Robert J.,Abrams, Kristin,Garceau, Norman Y.,Kamath, Ajith V.,Manley, Christopher M.,Lilley, Susan C.,Otte, Douglas A.,Scott, Dennis O.,Sheils, Alissa L.,Tess, David A.,Vellekoop, A. Samuel,Zhang, Yan,Lam, Kelvin T.
, p. 307 - 310 (2007/10/03)
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
OXINDOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE TYPE 2 INHIBITORS
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Page/Page column 15, (2008/06/13)
The present invention provides compounds, methods and kits for treatment of disease states or disorders mediated by PDE2. Oxindole derivatives are provided which have therapeutic use and as PDE2 inhibitors.
Tricyclic oxindole antiinflammatory agents
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, (2008/06/13)
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents useful in the treatment of rheumatoid arthritis.
