- Benzoquinone derivative, pharmaceutical composition, and applications thereof
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The invention discloses a benzoquinone derivative, a pharmaceutical composition, and applications thereof. According to the invention, the benzoquinone derivative (I), and the stereoisomer or the pharmaceutically acceptable salt thereof possess a structure disclosed in the invention. The benzoquinone derivative possesses excellent inhibition effect on STAT3 level both in vivo and in vitro, and further, the benzoquinone derivative is capable of inhibiting balling capacity of cancer cells.
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Paragraph 0256-0259
(2019/11/29)
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- Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203
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The anti-tubercular activity of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo [1,2-a]pyridine-3-carboxamide (Q203) is modified by varying its side chain. In this study, we synthesized Q203 analogues with different side
- Kang, Sunhee,Kim, Young Mi,Kim, Ryang Yeo,Seo, Min Jung,No, Zaesung,Nam, Kiyean,Kim, Sanghee,Kim, Jaeseung
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p. 807 - 815
(2016/10/24)
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- ANTI-INFECTIVE COMPOUNDS
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The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
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Page/Page column 31; 32
(2015/02/25)
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- Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability
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Previously, the lead compound 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide was identified in our anti-tuberculosis drug discovery program. Although this compound demonstrated excellent in vitro activity, it did not meet the expe
- Tangallapally, Rajendra P.,Lee, Robin E.B.,Lenaerts, Anne J.M.,Lee, Richard E.
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p. 2584 - 2589
(2007/10/03)
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