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5-bromo-2-methylbenzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 854633-21-9 Structure
  • Basic information

    1. Product Name: 5-bromo-2-methylbenzamide
    2. Synonyms: 5-bromo-2-methylbenzamide;IENXGTOPRPDOAE-UHFFFAOYSA-N
    3. CAS NO:854633-21-9
    4. Molecular Formula: C8H8BrNO
    5. Molecular Weight: 214.05922
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 854633-21-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-bromo-2-methylbenzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-bromo-2-methylbenzamide(854633-21-9)
    11. EPA Substance Registry System: 5-bromo-2-methylbenzamide(854633-21-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 854633-21-9(Hazardous Substances Data)

854633-21-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 854633-21-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,4,6,3 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 854633-21:
(8*8)+(7*5)+(6*4)+(5*6)+(4*3)+(3*3)+(2*2)+(1*1)=179
179 % 10 = 9
So 854633-21-9 is a valid CAS Registry Number.

854633-21-9Relevant articles and documents

Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy

Boshta, Nader M.,Bua, Silvia,Lee, Sang-Yong,Mirza, Salahuddin,Namasivayam, Vigneshwaran,Perotti, Arianna,Supuran, Claudiu T.,Müller, Christa E.

, p. 1187 - 1206 (2021/10/27)

Nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) catalyzes the hydrolysis of extracellular nucleotides. It is expressed by immune cells and some carcinomas,e.g.of kidney and colon. Together with ecto-5′-nucleotidase (CD73), NPP3 produces immunosuppres

As opioid receptor antagonists or inverse agonists of the novel compounds

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Paragraph 0335-0337; 0338-0340, (2016/10/08)

Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

FAK AND FLT3 INHIBITORS

-

Page/Page column 105, (2014/03/22)

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase

Currie, Kevin S.,Kropf, Jeffrey E.,Lee, Tony,Blomgren, Peter,Xu, Jianjun,Zhao, Zhongdong,Gallion, Steve,Whitney, J. Andrew,Maclin, Deborah,Lansdon, Eric B.,Maciejewski, Patricia,Rossi, Ann Marie,Rong, Hong,Macaluso, Jennifer,Barbosa, James,Di Paolo, Julie A.,Mitchell, Scott A.

, p. 3856 - 3873 (2014/05/20)

Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indications, but its clinical progress has been hampered by dose-limiting adverse effects that have been attributed, at least in part, to the off-target activities of 1. It is expected that a more selective Syk inhibitor would provide a greater therapeutic window. Herein we report the discovery and optimization of a novel series of imidazo[1,2-a]pyrazine Syk inhibitors. This work culminated in the identification of GS-9973, 68, a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.

FAK INHIBITORS

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Page/Page column 103, (2012/09/10)

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.

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