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2-Fluoro-3-hydroxyphenylboronic acid is a boronic acid derivative characterized by the presence of a fluorine and a hydroxyl group attached to a phenyl ring. It is a versatile chemical compound that belongs to the class of boronic acids and is widely used in various applications due to its unique properties.

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  • 855230-60-3 Structure
  • Basic information

    1. Product Name: 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
    2. Synonyms: 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID;2-Fluoro-3-hydroxybenzeneboronicacid96%
    3. CAS NO:855230-60-3
    4. Molecular Formula: C6H6BFO3
    5. Molecular Weight: 155.92
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 855230-60-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID(855230-60-3)
    11. EPA Substance Registry System: 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID(855230-60-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 855230-60-3(Hazardous Substances Data)

855230-60-3 Usage

Uses

Used in Organic Synthesis:
2-Fluoro-3-hydroxyphenylboronic acid is used as a reagent in Suzuki-Miyaura cross-coupling reactions, which are crucial for the formation of carbon-carbon bonds. This application is significant in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
As a building block, 2-Fluoro-3-hydroxyphenylboronic acid is utilized in the preparation of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
This boronic acid derivative is also employed in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals that enhance crop protection and productivity.
Used in Fine Chemicals Synthesis:
2-Fluoro-3-hydroxyphenylboronic acid serves as an important intermediate in the synthesis of biologically active compounds, which are essential in various industries, including fragrances, dyes, and other specialty chemicals.
Overall, 2-Fluoro-3-hydroxyphenylboronic acid is a multifaceted chemical compound with a wide range of applications across different industries, primarily due to its unique structure and reactivity in organic synthesis and its potential in the development of pharmaceuticals, agrochemicals, and fine chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 855230-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,5,2,3 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 855230-60:
(8*8)+(7*5)+(6*5)+(5*2)+(4*3)+(3*0)+(2*6)+(1*0)=163
163 % 10 = 3
So 855230-60-3 is a valid CAS Registry Number.

855230-60-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-Fluoro-3-hydroxyphenyl)boronic acid

1.2 Other means of identification

Product number -
Other names (2-fluoro-3-hydroxyphenyl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:855230-60-3 SDS

855230-60-3Relevant articles and documents

Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships

Gràcia, Jordi,Buil, Maria Antonia,Castro, Jordi,Eichhorn, Peter,Ferrer, Manel,Gavaldà, Amadeu,Hernández, Bego?a,Segarra, Victor,Lehner, Martin D.,Moreno, Imma,Pagès, Lluís,Roberts, Richard S.,Serrat, Jordi,Sevilla, Sara,Taltavull, Joan,Andrés, Miriam,Cabedo, Judit,Vilella, Dolors,Calama, Elena,Carcasona, Carla,Miralpeix, Montserrat

, p. 10479 - 10497 (2016/12/16)

Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl cyclase. Its intracellular levels are tightly controlled by a family of cyclic nucleotide degrading enzymes, the PDEs. In recent years, cyclic nucleotide phosphodiesterase type 4 (PDE4) has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases, particularly in the management of asthma and COPD. Here we describe our efforts to discover novel, highly potent inhaled inhibitors of PDE4. Through structure based design, with the inclusion of a variety of functional groups and physicochemical profiles in order to occupy the solvent-filled pocket of the PDE4 enzyme, we modified the structure of our oral PDE4 inhibitors to reach compounds down to picomolar enzymatic potencies while at the same time tackling successfully an uncovered selectivity issue with the adenosine receptors. In vitro potencies were demonstrated in a rat lung neutrophilia model by administration of a suspension with a Penn-Century MicroSprayer Aerosolizer.

(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors

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Page/Page column 30; 31, (2010/07/03)

New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

2, 4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER

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Page/Page column 89, (2010/02/15)

The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their prep

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