352303-67-4 Usage
Description
2-FLUORO-3-METHOXYPHENYLBORONIC ACID is an organic compound that features a boronic acid functional group with a fluorine atom at the 2nd position and a methoxy group at the 3rd position on a phenyl ring. 2-FLUORO-3-METHOXYPHENYLBORONIC ACID is known for its reactivity and utility in various chemical reactions, particularly in the field of organic synthesis.
Uses
Used in Chemical Synthesis:
2-FLUORO-3-METHOXYPHENYLBORONIC ACID is used as a reactant for regioselective Suzuki coupling, a widely employed method for the formation of carbon-carbon bonds, particularly in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
2-FLUORO-3-METHOXYPHENYLBORONIC ACID is used as a reactant for the preparation of inhibitors of 17β-hydroxysteroid dehydrogenase type 1, which are important for the development of drugs targeting various hormonal disorders and diseases.
Used in Organic Chemistry Research:
2-FLUORO-3-METHOXYPHENYLBORONIC ACID is used as a reactant for the preparation of boronic esters, which are versatile intermediates in organic chemistry and can be employed in the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 352303-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,3,0 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 352303-67:
(8*3)+(7*5)+(6*2)+(5*3)+(4*0)+(3*3)+(2*6)+(1*7)=114
114 % 10 = 4
So 352303-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BFO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4,10-11H,1H3
352303-67-4Relevant articles and documents
Base free aryl coupling of diazonium compounds and boronic esters: Self-activation allowing an overall highly practical process
Bonin, Helene,Delbrayelle, Dominique,Demonchaux, Patrice,Gras, Emmanuel
supporting information; experimental part, p. 2677 - 2679 (2010/07/08)
Boronic esters have long been considered as poor partners in cross-coupling reactions with arene diazoniums. Here is reported an unprecedented application of self-activated boronic esters in a base-free cross-coupling reaction with diazonium salts under mild and user friendly conditions.
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.
Kopka, Ihor E,Lin, Linus S,Mumford, Richard A,Lanza Jr., Thomas,Magriotis, Plato A,Young, David,DeLaszlo, Stephen E,MacCoss, Malcolm,Mills, Sander G,Van Riper, Gail,McCauley, Ermengilda,Lyons, Kathryn,Vincent, Stella,Egger, Linda A,Kidambi, Usha,Stearns, Ralph,Colletti, Adria,Teffera, Yohannes,Tong, Sharon,Owens, Karen,Levorse, Dorothy,Schmidt, John A,Hagmann, William K
, p. 2415 - 2418 (2007/10/03)
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.