85622-96-4

Basic information

• Product Name: 8-(N-methyl)mitozolomide
• Synonyms: 8-(N-methyl)mitozolomide
• CAS NO: 85622-96-4
• Molecular Formula: C8H9ClN6O2
• Molecular Weight: 256.64906
• Mol File: 85622-96-4.mol

Chemical Properties

• Appearance: /
• Density: 1.73g/cm³
• Refractive Index: 1.755
• CAS DataBase Reference: 8-(N-methyl)mitozolomide(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(N-methyl)mitozolomide(85622-96-4)
• EPA Substance Registry System: 8-(N-methyl)mitozolomide(85622-96-4)

Safety Data

• Hazardous Substances Data: 85622-96-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9ClN6O2/c1-10-7(16)5-6-12-13-15(3-2-9)8(17)14(6)4-11-5/h4H,2-3H2,1H3,(H,10,16)

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 113942-57-7 3-(2-chloroethyl)-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carbonyl chloride 
• 74-89-5 methylamine 
• 113942-32-8 3-(2-chloroethyl)-3,4-dihydro-4-oxoimidazo<5,1-d><1,2,3,5>tetrazine-8-carboxylic acid 
• 85622-95-3 mitozolomide 
• 113942-31-7 benzyl 3-(2-chloroethyl)-3H-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carboxylate 
• 53525-66-9 4-amino-5-(N-methylcarbamoyl)imidazole 

Relevant articles and documents

TETRAZINE DERIVATIVES

[3H]-Imidazo[5,1-d] -1,2,3,5-tetrazin-4-one derivatives of the formula:wherein R1represents hydrogen, or an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms, each such group being unsubstituted or substituted by from one to three substituents selected from halogen atoms, alkoxy, alkylthio, alkylsulphinyl and alkylsulphonyl groups containing up to 4 carbon atoms, and optionally substituted phenyl groups, or R1represents a cycloalkyl group containing from 3 to 8 carbon atoms, and R2 represents a carbamoyl group optionally N-substituted by one or two groups selected ftom alkyl and alkenyl groups containing up to 4 carbon atoms, and cycloalkyl groups containing 3 to 8 carbon atoms, are new therapeutically useful compounds possessing antineoplastic and immunomodulatory activity

Antitumor Imidazotetrazines. 20. Preparation of the 8-Acid Derivative of Mitozolomide and Its Utility in the Preparation of Active Antitumor Agents

The preparation of 3-(2-chloroethyl)-4-oxo-3H-imidazo-1,2,3,5-tetrazine-8-carboxylic acid, a key derivative of mitozolomide in our exploration of the structure-activity relationships of this class of antitumor agents, is described.The facile conver

Antitumor Imidazotetrazines. 14. Synthesis and Antitumor Activity of 6- and 8-Ssubstituted Imidazo-1,2,3,5-tetrazinones and 8-Substituted Pyrazolo-1,2,3,5-tetrazinones

The systematic variation of the potent antitumor agent mitozolomide (1) is extended to cover alteration of substituents at position 6 and 8 and to change the imidazo-1,2,3,5-tetrazinone (6) skeleton to the isomeric pyrazolo-1,2,3,5-tetrazino