856758-58-2

Basic information

• Product Name: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-
• Synonyms: Benzenemethanamine, 4-chloro-2-fluoro-α-methyl-, (αR)-;4-chloro-2-fluoro-a-Methyl-;(R)-1-(4-chloro-2-fluorophenyl)ethanamine;BENZENEMETHANAMINE, 4-CHLORO-2-FLUORO-ALPHA-METHYL-, (ALPHAR)-;Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-
• CAS NO: 856758-58-2
• Molecular Formula: C₈H₉ClFN
• Molecular Weight: 173.617
• Product Categories: API intermediates
• Mol File: 856758-58-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(856758-58-2)
• EPA Substance Registry System: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(856758-58-2)

Safety Data

• Hazardous Substances Data: 856758-58-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)is used as a key component in the synthesis of drug molecules for the treatment of various diseases, including cancer, cardiovascular disorders, and neurological conditions. Its chiral nature and critical stereochemistry make it a valuable building block in the development of new and effective medications.
Used in the Synthesis of Therapeutic Agents:
In the pharmaceutical industry, Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)is utilized in the synthesis of potential therapeutic agents, capitalizing on its unique chemical properties and stereochemistry. Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)plays a crucial role in the development of innovative medications with improved efficacy and selectivity.
Used in Drug Design and Optimization:
The chiral nature of Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)allows for the exploration of its stereoisomers in drug design and optimization processes. By understanding the impact of stereochemistry on pharmacological activity, researchers can develop more targeted and effective drug candidates with reduced side effects.

Upstream product

• 1442445-18-2 (S)-N-(1-(4-chloro-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide 
• 856562-68-0 (S)-N-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 175711-83-8 4’-chloro-2’-fluoroacetophenone 

Downstream Products

• 1442445-27-3 (R)-5-bromo-N-(1-(4-chloro-2-fluorophenyl)ethyl)benzene-1,2-diamine 
• 1442445-28-4 (R)-6-bromo-1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazole 
• 1442445-29-5 (R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1442445-30-8 (R)-1-(1-(4-chloro-2-fluorophenyl)ethyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazole 
• 1442445-31-9 (R)-tert-butyl 2-(4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1442445-02-4 (4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-pyrrolidin-2-yl)methanone 
• 1442445-36-4 1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole 
• 1442445-37-5 (R)-tert-butyl 2-((R)-4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylpiperazine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1442445-07-9 ((R)-4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylpiperazin-1-yl)((R)-pyrrolidin-2-yl)methanone 
• 1442445-26-2 (R)-5-bromo-N-(1-(4-chloro-2-fluorophenyl)ethyl)-2-nitroaniline 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS

Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.