856845-64-2

Basic information

• Product Name: 3-ISOPROPYL-PIPERAZIN-2-ONE
• Synonyms: 3-isopropylpiperazin-2-one(SALTDATA: FREE)
• CAS NO: 856845-64-2
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.2
• Mol File: 856845-64-2.mol

Chemical Properties

• Boiling Point: 296.6°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 0.966g/cm³
• Vapor Pressure: 0.00142mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-ISOPROPYL-PIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ISOPROPYL-PIPERAZIN-2-ONE(856845-64-2)
• EPA Substance Registry System: 3-ISOPROPYL-PIPERAZIN-2-ONE(856845-64-2)

Safety Data

• Hazardous Substances Data: 856845-64-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-ISOPROPYL-PIPERAZIN-2-ONE is used as a building block for the synthesis of various pharmaceuticals due to its ability to serve as a versatile intermediate in organic synthesis, contributing to the development of new drugs and biologically active substances.
Used in Agrochemical Industry:
3-ISOPROPYL-PIPERAZIN-2-ONE is used as a key intermediate in the production of agrochemicals, facilitating the creation of substances that can be utilized in agriculture for pest control and crop protection.
Used in Organic Synthesis:
3-ISOPROPYL-PIPERAZIN-2-ONE is used as a versatile intermediate in organic synthesis, enabling researchers and chemists to explore its potential applications in drug discovery and development, as well as in the creation of other chemical compounds with specific properties and functions.

InChI:InChI=1/C7H14N2O/c1-5(2)6-7(10)9-4-3-8-6/h5-6,8H,3-4H2,1-2H3,(H,9,10)

Upstream product

• 609-12-1 ethyl 2-bromoisovalerate 
• 107-15-3 ethylenediamine 
• 10323-40-7 2-bromoisovaleric acid 
• 1685-33-2 N-[(benzyloxy)carbonyl]-D-valine 
• 1456693-00-7 (R)-benzyl (1-((2,2-dimethoxyethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1456693-01-8 (R)-benzyl 2-isopropyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate 
• 1456693-02-9 (R)-benzyl 2-isopropyl-3-oxopiperazine-1-carboxylate 

Downstream Products

• 1456693-55-2 (R)-methyl 1-isopropyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo [1,2-a]pyrazine-8-carboxylate 

Relevant articles and documents

Synthetic method of chiral piperazidone derivative

The invention relates to a synthetic method of a chiral piperazidone derivative. The synthetic method comprises the following steps: performing an oxidation reaction on ethanolamine with a protectivegroup in a formula (I) to obtain aminoacetaldehyde with a protective group in a formula (II); in an alcohol solvent, performing a reduced amination reaction on the aminoacetaldehyde with the protective group in the formula (II) and amino acid ester in the presence of a reducing agent to obtain the chiral piperazidone derivative in the formula (II), wherein the reduced amination reaction temperature is -10 DEG C to 0 DEG C, and the amino acid ester is L-type amino acid ester or D-type amino acid ester; and in the alcohol solvent, performing a de-protection reaction on the chiral piperazidone derivative in the formula (II) and forming a ring to obtain a chiral piperazidone derivative in a formula (IV), wherein a reaction route is shown as follows: the protective group X is benzoxo carbonyl or tert-butyoxo carbonyl; R is methyl, ethyl, isopropyl, isobutyl, hydroxyethyl, benzyl, p-hydroxybenzyl and the like; and R' is methyl, ethyl and the like.

NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK

The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases s

COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS

Provided herein are compounds and pharmaceutically acceptable salts thereof that are useful therapeutics for acute coronary syndrome and related disorders.

LIVER X RECEPTOR MODULATORS

Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.

LIVER X RECEPTION MODULATORS

Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.