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CAS

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856850-18-5

2-(bromomethyl)-4-chloropyridine is a halogenated pyridine derivative with the molecular formula C6H5BrClN. It is a pale yellow to yellowish-brown liquid at room temperature and is soluble in polar solvents such as ethanol and dimethyl sulfoxide. This chemical compound is commonly used as a building block in organic synthesis.

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  • 856850-18-5 Structure

  • Basic information

    1. Product Name: 2-(broMoMethyl)-4-chloropyridine
    2. Synonyms: 2-(broMoMethyl)-4-chloropyridine
    3. CAS NO:856850-18-5
    4. Molecular Formula: C6H5BrClN
    5. Molecular Weight: 206.4676
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 856850-18-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(broMoMethyl)-4-chloropyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(broMoMethyl)-4-chloropyridine(856850-18-5)
    11. EPA Substance Registry System: 2-(broMoMethyl)-4-chloropyridine(856850-18-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 856850-18-5(Hazardous Substances Data)

856850-18-5 Usage

Uses

Used in Pharmaceutical Industry:
2-(bromomethyl)-4-chloropyridine is used as a versatile intermediate for the preparation of various biologically active compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-(bromomethyl)-4-chloropyridine is used as a key component in the synthesis of pesticides. Its reactivity and functional groups make it suitable for the creation of effective and targeted agrochemicals.
Safety Precautions:
It is important to handle 2-(bromomethyl)-4-chloropyridine with caution, as it is flammable and can cause skin and eye irritation upon contact. Proper safety measures, such as wearing protective gear and working in a well-ventilated area, should be taken to minimize risks.

Check Digit Verification of cas no

The CAS Registry Mumber 856850-18-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,6,8,5 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 856850-18:
(8*8)+(7*5)+(6*6)+(5*8)+(4*5)+(3*0)+(2*1)+(1*8)=205
205 % 10 = 5
So 856850-18-5 is a valid CAS Registry Number.

856850-18-5Downstream Products

856850-18-5Relevant articles and documents

Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors

Huang, Yadan,Wu, Xu-Nian,Zhou, Qian,Wu, Yinuo,Zheng, Dongxiao,Li, Zhe,Guo, Lei,Luo, Hai-Bin

, p. 15852 - 15863 (2020/12/23)

To validate the hypothesis that Tyr748 is a crucial residue to aid the discovery of highly selective phosphodiesterase 8A (PDE8A) inhibitors, we identified a series of 2-chloroadenine derivatives based on the hit clofarabine. Structure-based design targeting Tyr748 in PDE8 resulted in the lead compound 3a (IC50 = 0.010 μM) with high selectivity with a reasonable druglike profile. In the X-ray crystal structure, 3a bound to PDE8A with a different mode from 3-isobutyl-1-methylxanthine (a pan-PDE inhibitor) and gave a H-bond of 2.7 ? with Tyr748, which possibly interprets the 220-fold selectivity of 3a against PDE2A. Additionally, oral administration of compound 3a achieved remarkable therapeutic effects against vascular dementia (VaD), indicating that PDE8 inhibitors could serve as potential anti-VaD agents.

One-pot directed alkylation/deprotection strategy for the synthesis of substituted pyrrole[3,4-d]pyridazinones

Nair, Reji N.,Bannister, Thomas D.

, p. 1764 - 1770 (2015/05/27)

In the course of a structure-activity relationship study of pyrrole[3,4-d]pyridazinones, we optimized conditions for a one-pot directed lithiation/alkylation reaction that also promoted in situ cleavage of a tert-butoxycarbonyl (Boc) protecting group on t

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