3678-63-5

Basic information

• Product Name: 4-Chloro-2-picoline
• Synonyms: 4-CHLORO-2-METHYL-PYRIDINE;4-CHLORO-2-PICOLINE;2-methyl-4-chloropyridine;2-Methyl-4-Chloropyridine HCl;4-Chloro-2-methylpyridine HCl Salt;4-CHLORO-2-PICOLINE 98%;4-CHLORO-2-METHYLPYRIDINE (4-CHLORO-2-PICOLINE);2-Picoline, 4-chloro- (6CI,7CI,8CI)
• CAS NO: 3678-63-5
• Molecular Formula: C₆H₆ClN
• Molecular Weight: 127.57
• EINECS: -0
• Product Categories: Pyridine;Pyridines;pyridine series;Aromatics;Heterocycles;Miscellaneous Reagents
• Mol File: 3678-63-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 62-64°C 20mm
• Flash Point: 65.6 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.156
• Vapor Pressure: 2.7mmHg at 25°C
• Refractive Index: 1.5205
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• PKA: 4.20±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-2-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-picoline(3678-63-5)
• EPA Substance Registry System: 4-Chloro-2-picoline(3678-63-5)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 23-26-37/39
• Hazardous Substances Data: 3678-63-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

4-Chloro-2-picoline (cas# 3678-63-5) is a compound useful in organic synthesis.

InChI:InChI=1/C6H6ClN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 931-19-1 2-methylpyridine N-oxide 
• 10025-87-3 trichlorophosphate 
• 26452-80-2 2,4-dichloropyridine 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 18615-86-6 2-Methyl-4-hydroxypyridine 
• 859299-13-1 N-benzyl-2-methylpyridin-4-amine 
• 100367-70-2 4-Mercapto-2-methyl-pyridin 
• 856850-18-5 2-(bromomethyl)-4-chloropyridine 
• 5470-22-4 4-chloropicolinic acid 
• 408533-46-0 2-Methyl-pyridyl-(4)-sulfonsaeure 
• 93856-98-5 4-chloro-2-propylpyridine 
• 228401-40-9 {4-[(2-methylpyridin-4-yl)oxy]phenyl} amine 
• 844818-54-8 4-(4-Fluoro-phenyl)-2-methyl-pyridine 
• 166954-04-7 1-benzyl-4-(2-methyl-4-pyridinyl)piperazine 
• 945998-84-5 2-methoxy-5-(2-methyl-pyridin-4-yl)-benzaldehyde 
• 437384-24-2 2-(4-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone 
• 869663-76-3 2-fluoro-4-(2-methylpyridin-4-yloxy)phenylamine 

Relevant articles and documents

Chemoselective sp 2-sp3 cross-couplings: Iron-catalyzed alkyl transfer to dihaloaromatics

The chemoselective functionalization of a range of dihaloaromatics with methyl, cyclopropyl, and higher alkyl Grignard reagents via iron-catalyzed cross-coupling is described. The site selectivity of C-X (X = halogen) activation is determined by factors such as the position of the halogen on the ring, the solvent, and the nucleophile. A one-pot protocol for the chemoselective synthesis of mixed dialkyl heterocycles is achieved solely employing iron catalysis.